Searching for an ideal cervical cancer screening model to reduce false-negative errors in a country with high prevalence of cervical cancer.

Searching for an ideal cervical cancer screening model to reduce false-negative errors in a country with high prevalence of cervical cancer. J Obstet Gynaecol. 2019 Jul 25;:1-7 Authors: Song T, Seong SJ, Lee SK, Kim BR, Ju W, Kim KH, Nam K, Sim JC, Kim TJ Abstract The purpose of this study was to develop an ideal cervical cancer screening model to reduce false-negative errors in Korea where there is a high prevalence of cervical cancer. We conducted a cross-sectional study including 33,531 women who underwent routine cervical cancer screening in Korea. Colposcopic examinations were performed after abnormal results on their screening tests. Diagnostic capacities including sensitivity, specificity, and false-negative rate of each screening scenario were analysed at the CIN1 or worse (CIN1+) threshold with colposcopic biopsy results considered the gold standard. A total of 4117 women had valid results for Papanicolaou (Pap) cytology, human papilloma virus (HPV) tests, cervicography, and colposcopically directed biopsy were included in this study. The disease prevalence of CIN1+ was 38.1%. Pap-alone resulted in the highest false-negative rate of 46.9%, followed by HPV-alone at 25.1%, cervicography-alone at 18.7%, Pap/HPV-combined at 15.0%, Pap/cervicography-combined at 6.9% and Pap/HPV/cervicography-combined at 2.9% in a sample of 1570 women with CIN1+ lesions. Therefore, cervicography demonstrated excellent performance for the detection of CIN or cervical ca...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

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CONCLUSION: Cervical cancer can be detected by molecular techniques such as (1) PCR, (2) visual acetic acid method, (3) DNA Hybrid II test, (4) liquid based cytology, (5) Pap-Smear techniques, and (6) colposcopy techniques. Early detection of CC is very much in need; Cryotherapy or LEEP (Loop electro surgical excision procedure) can be conducted during the first and second stages of CC. Some metabolic changes in the human body such as fluctuating levels of insulin and triglycerides and increased activity of adiponectin may lead to CC. These contributing factors, such as adipokines, can be used as bio-markers for the CC det...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research
This study aims to investigate the prevalence of cervical intraepithelial neoplasia 1 or worse (CIN1+) and CIN3 or worse (CIN3+) in patients with ASCUS in China to provide insight into appropriate management for Chinese health care. In a retrospective cross-sectional study, patients who underwent liquid-based thin layer cytology and human papillomavirus (HPV) co-testing at the Peking Union Medical College Hospital between January 2014 and January 2017, and had ASCUS results on liquid-based thin layer cytology test and underwent follow-up and colposcopic biopsy were included. Age, HPV DNA test, and pathological outcomes we...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
(see:Startup uses phone, light and AI to detect cervical cancer)Israeli startup MobileODT has created the Eva System, which uses an Automated Visual Evaluation (AVE) algorithm that it says can detect cervical cancer by simply examining an image of the cervix (Courtesy) Israeli startup MobileODT has created the Eva System, which uses an Automated Visual Evaluation (AVE) algorithm that it says can detect cervical cancer by simply examining an image of the cervix (Courtesy) Israeli start-up MobileODT says it can detect cervical cancer more accurately and inexpensively than the standard colposcopy method used today, by creatin...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Source Type: blogs
Conclusions: Self-collection for HPV testing by women living in isolated communities is highly efficient and has potential for cost-effective screening by taking advantage of existing support networks, such as the local police service.Acta Cytologica
Source: Acta Cytologica - Category: Cytology Source Type: research
ConclusionCervicography and Pap co-testing had superior screening capacity and cost-effectiveness for detection of preinvasive cervical lesions than HPV and Pap co-testing and may be an effective and cost-saving screening strategy in clinical practice in country with a high prevalence of cervical cancer.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conclusions: Onclarity is clinically validated for cotesting in NILM women. Genotyping actionably stratifies women at greater CIN3 or higher risk. PMID: 30649177 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
Authors: Göktuğ Kadıoğlu B, Çınar Tanrıverdi E, Alay H, Uçar M Abstract Cervical cancer is a common female cancer that could be diagnosed early with screening methods. Almost all cases are caused by human papilloma virus (HPV) infection. Therefore, detecting the presence of HPV DNA is important for early diagnosis and treatment. Regular determination of screening tests enables early detection of patients with the risk of cervical cancer. For this purpose, since August 2014 a new screening program has been carried out by Early Diagnosis, Screening and Training of Cancer Centers (KETEM). The a...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
A recent article indicated that HPV testing is superior to the Pap smear for detecting precancerous lesions of the cervical epithelium (see:HPV test is better than Pap smear at detecting precancerous cervical changes). Has the Pap smear outlived its usefulness in cancer screening programs? Below is a key passage from the article:A new study found that the HPV test was better than the Pap smear in detecting precancerous changes that can lead to cervical cancer. A test for HPV detects precancerous changes of the cervix earlier and more accurately than the Pap smear....The randomized, controlled study...showed that the human ...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Cytopathology Healthcare Innovations Medical Research Public Health Surgical Pathology Source Type: blogs
Publication date: May–June 2018Source: Journal of the American Society of Cytopathology, Volume 7, Issue 3Author(s): Maren Y. Fuller, Roxanne R. Mody, Eric Luna, Donna Armylagos, Mary R. Schwartz, Dina R. Mody, Yimin GeIntroductionHigh-risk human papillomavirus (hrHPV) testing is important in cervical cancer screening and management algorithms. Roche (Pleasanton, Calif.) cobas hrHPV testing is commonly performed on both ThinPrep (TP) and SurePath (SP) samples, but performance of these platforms has not been fully investigated in the literature.Materials and MethodsRoche hrHPV testing was performed on 47,885 (TP = 18,...
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Objective The aim of the study was to assess the impact of human papillomavirus (HPV) awareness and knowledge on physiological state and quality of life of women referred to colposcopy and/or HPV testing. Materials and Methods A cross-sectional study was carried out at University Hospital, Belgrade, Serbia. The women with abnormal Pap test results obtained at the primary care centers requiring colposcopy and/or HPV testing were included. Before gynecological examination, participants filled the questionnaire on demographic characteristics, gynecological history, questionnaire for the evaluation of HPV awareness and HP...
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Original Research Articles: Cervix and HPV Source Type: research
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