Effects of Methamphetamine Exposure on Fear Learning and Memory in Adult and Adolescent Rats.
Effects of Methamphetamine Exposure on Fear Learning and Memory in Adult and Adolescent Rats. Neurochem Res. 2019 Jul 23;: Authors: Luikinga SJ, Perry CJ, Madsen HB, Lawrence AJ, Kim JH Abstract Methamphetamine (meth) use is often comorbid with anxiety disorders, with both conditions predominant during adolescence. Conditioned fear extinction is the most widely used model to study the fear learning and regulation that are relevant for anxiety disorders. The present study investigates how meth binge injections or meth self-administration affect subsequent fear conditioning, extinction and retrieval in adult and adolescent rats. In experiment 1, postnatal day 35 (P35-adolescent) and P70 (adult) rats were intraperitoneally injected with increasing doses of meth across 9 days. At P50 or P85, they underwent fear conditioning followed by extinction and test. In experiments 2a-c, P35 or P70 rats self-administered meth for 11 days then received fear conditioning at P50 or P85, followed by extinction and test. We observed that meth binge exposure caused a significant disruption of extinction retrieval in adult but not adolescent rats. Interestingly, meth self-administration in adolescence or adulthood disrupted acquisition of conditioned freezing in adulthood. Meth self-administration in adolescence did not affect conditioned freezing in adolescence. These results suggest that intraperitoneal injections of high doses of meth and meth self-administration...
ConclusionAlthough BD awareness has increased, important disparities persist. Knowledge of BD’s impact on risk has increased; knowledge about masking and BD discussions with providers has not. Most women want to know their BD, would not feel anxious or confused as a result of knowing, and would feel empowered to make decisions. The federal BD notification legislation presents an opportunity to improve awareness and knowledge and encourage BD conversations with providers.Graphical abstract
Publication date: Available online 20 November 2019Source: International Journal of PsychophysiologyAuthor(s): Yuanxiao Ma, Na Hu, Guangzeng Liu, Xu ChenAbstractAdult attachment is particularly known for the modulating role of caregiving motivation and behavior. Although most studies consider attachment style relatively stable, it may also be affected by various situational factors, and these temporary fluctuations are related to meaningful behaviors. Using functional magnetic resonance imaging, the present study aims to examine whether neural responses to infant faces are moderated by participants' state attachment. The r...
Conclusions Depression is common among NH residents in Jordan and is associated significantly with poor QoL. This study yielded empirical data that may be used to develop strategies to enhance or promote the mental health status and QoL of NH residents in Jordan.
Conclusions/Implications for Practice: Cognitive dysfunction is commonly seen in patients with cancer receiving chemotherapy. Chemotherapy, age, and psychological factors increase susceptibility to cognitive dysfunction in adult patients with cancer. Oncology nurses should be aware that patients with cancer may be extremely vulnerable to cognitive dysfunction. Furthermore, age and psychological factors must be considered when developing symptom management and supportive care intervention programs to reduce the incidence of negative cognitive outcomes in this population.
Conclusions The SCNS-ST9-C is a brief, low-burden, and psychometrically valid instrument that may be applied in ethnically Chinese settings. This tool takes 1–2 minutes to complete. Further testing of the psychometrics of this instrument in different cancer populations is recommended.
Pancreatic cystic lesions (PCLs) are commonly encountered, with a prevalence of over 40% in patients undergoing cross-sectional imaging; the incidence increases with age.1 The vast majority are discovered incidentally, are branch duct intraductal papillary mucinous neoplasms (IPMNs), and will never progress to cancer. Despite this, and because the guidelines are controversial and based on little evidence, the management of PCLs continues to create anxiety and frustration for both the patient and the gastroenterologist.
Condition: Wound Heal Intervention: Other: Music intervention Sponsor: KK Women's and Children's Hospital Completed
Conditions: Surgery; Anxiety Intervention: Other: Music Sponsor: Children's Surgical Center, Cambodia Recruiting
The childhood experience that is linked to borderline personality disorder. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
This facial symptom can be irritating. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do