The neuropathology of fatal encephalomyelitis in human Borna virus infection

This study aims at raising awareness to human bornavirus encephalitis as differential diagnosis in lymphocytic scleros ing panencephalomyelitis. A higher attention to human BoDV-1 infection by health professionals may likely increase the detection of more cases and foster a clearer picture of the disease.
Source: Acta Neuropathologica - Category: Neurology Source Type: research

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Publication date: 14–20 September 2019Source: The Lancet, Volume 394, Issue 10202Author(s): Arun Venkatesan, Benedict D Michael, John C Probasco, Romergryko G Geocadin, Tom Solomon
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 14–20 September 2019Source: The Lancet, Volume 394, Issue 10202Author(s): Amir Abdoli
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 14–20 September 2019Source: The Lancet, Volume 394, Issue 10202Author(s): Shampa Ghosh, Manchala Raghunath, Jitendra Kumar Sinha
Source: The Lancet - Category: General Medicine Source Type: research
Authors: Daida K, Nishioka K, Takanashi M, Kobayashi M, Yoshikawa K, Kusunoki S, Yokoyama K, Hattori N Abstract A healthy 28-year-old woman presented suddenly with intractable status epilepticus: a focal seizure evolved into a generalized seizure preceded by a high fever. Brain magnetic resonance imaging indicated bilateral hyperintensities in the hippocampus on T2-weighted imaging. Electroencephalograms continuously demonstrated diffuse sharp waves and poly-spikes. Comprehensive immunomodulation therapies and anti-epileptic drugs did not lead to any improvements. We therefore diagnosed her with cryptogenic limbic ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionsC. burnetii is rarely transmitted by ticks, but we proved that it is present in the environment, so it may be a danger to humans. The most common co-occurrence after tick bite concernsC. burnetii andB. burgdorferi.
Source: Infection - Category: Infectious Diseases Source Type: research
Condition:   Encephalitis Interventions:   Diagnostic Test: CSF sampling;   Diagnostic Test: Blood sampling;   Diagnostic Test: Nasopharyngeal and rectal sampling Sponsors:   Institut Pasteur;   Centre De Coopération International En Recherche Agronomique Pour Le Développement;   Institut National de la Santé Et de la Recherche Médicale, France;   Institut Pasteur, Cambodia;   Institut de Recherche pour le Developpement;   National Institute of Hygie ne and Epidemiology, Vietna...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report that overnight incubation with NMDAR-Ab from patients, but not from healthy carriers, decreased the surface dynamics of D1R compared with NMDAR-Ab seronegative IgGs. This decrease was abolished, and even reversed, in D1R mutant that cannot physically interact with NMDAR. Overall, our data indicate that NMDAR-Ab from patients with psychotic symptoms alter the trafficking of D1R, likely through the surface crosstalk between NMDAR and D1R.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated demyelination has been associated with a range of clinical phenotypes, including acute disseminated encephalomyelitis (ADEM), ADEM followed by recurrent optic neuritis, aquaporin 4–negative neuromyelitis optica spectrum disorder, and less commonly, brainstem encephalitis.1 In contrast, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a clinical, radiologic, and pathologic diagnosis without an associated antibody.2,3 There have been few reported cases of pediatric CLIPPERS,4 and most have not cle...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Encephalitis, All Pediatric, All Demyelinating disease (CNS) Clinical/Scientific Notes Source Type: research
Publication date: Available online 11 September 2019Source: Autoimmunity ReviewsAuthor(s): Valerio Frazzini, Vi-Huong Nguyen-Michel, Marie-Odile Habert, Phintip Pichit, Emmanuelle Apartis, Vincent Navarro
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Abstract Microglia, as brain-resident macrophages, are the first line of defense against brain invading pathogens. Further, their dysfunction has been recognized to be closely associated with mounting CNS diseases. Of note, chronic HSV-1 infection leads to the persistent activation of microglia, which elicit a comprehensive response by generating certain factors with neurotoxic and neuroprotective effects. CNS infection with HSV-1 results in herpes simplex encephalitis and herpes simplex keratitis. Microglial immune response plays a crucial role in the development of these diseases. Moreover, HSV-1 infection is st...
Source: Critical Reviews in Microbiology - Category: Microbiology Authors: Tags: Crit Rev Microbiol Source Type: research
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