Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue.

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue.
Physiol Rev. 2019 Oct 01;99(4):1701-1763
Authors: Saxton SN, Clark BJ, Withers SB, Eringa EC, Heagerty AM
Abstract
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.
PMID: 31339053 [PubMed - in process]

Source: Physiological Reviews - July 26, 2019 Category: Physiology Authors: Saxton SN, Clark BJ, Withers SB, Eringa EC, Heagerty AM Tags: Physiol Rev Source Type: research