Inhibition of Histone Deacetylase 6 Protects Hippocampal Cells Against Mitochondria-mediated Apoptosis in a Model of Severe Oxygen-glucose Deprivation.

CONCLUSIONS: HDAC 6 inhibition, using Tub-A, protects against OGD-induced injury in HT22 cells by modulating Akt/GSK3β signaling and inhibiting mitochondria-mediated apoptosis.
PMID: 31339071 [PubMed - as supplied by publisher]

Source: Current Molecular Medicine - July 22, 2019 Category: Molecular Biology Authors: Chang P, Tian Y, Williams AM, Bhatti UF, Liu B, Li Y, Alam HB Tags: Curr Mol Med Source Type: research