Steric stabilization of phycobiliprotein loaded liposome through polyethylene glycol adsorbed cellulose nanocrystals and their impact on the gastrointestinal tract.

Publication date: Available online 25 July 2019Source: Food HydrocolloidsAuthor(s): Avinash Singh Patel, SuriyaPrakaash Lakshmibalasubramaniam, Balunkeswar NayakAbstractThe goal of the study was to encapsulate phycobiliprotein (PBP), a seaweed bioactive compound with the help of liposome and stabilized through cellulose nanocrystals (CNC). The study investigated the stability of CNC coating and the release of PBP compounds using a simulated human gastrointestinal tract (GIT) model. Adsorption of polyethylene glycol (PEG) with molecular weights of 400–4000 gmol-1 on desulfated CNCs (DCs) showed significant stability (p < 0.05) of liposomes during in-vitro GIT experiments. The effect of GIT phase on the quality characteristics of the sample revealed that the simulated gastric juice phase of GIT helps on desorption of polyethylene glycol from desulfated CNCs surface followed by precipitation of DCs. This phenomena confirmed the effective coalescence of liposomes in the gastric phase of the GIT. The liposomes stabilized through the higher molecular weight of PEG adsorbed with DCs (i.e., DPCs-4000, DPCs-1500, and DPCs-1000) displayed a higher degree of anti-coalescence behavior as compared to the lower molecular weight of PEG with desulfated CNCs (DPCs-600 and DPCs-400). However, liposomes stabilized through pure DCs displayed insignificant (p > 0.05) effect on the stability of PBP loaded liposomes. We concluded that the adsorption of PEG onto DCs surface was enough ...
Source: Food Hydrocolloids - Category: Food Science Source Type: research