Mitochondrial transplantation ameliorates acute limb  ischemia

Acute limb ischemia (ALI), the most challenging form of ischemia-reperfusion injury (IRI) in skeletal muscle tissue, leads to decreased skeletal muscle viability and limb function. Mitochondrial injury has been shown to play a key role in skeletal muscle IRI. In previous studies, we have demonstrated that mitochondrial transplantation (MT) is an efficacious therapeutic strategy to replace or to augment mitochondria damaged by IRI, allowing enhanced muscle viability and function in cardiac tissue.

Source: Journal of Vascular Surgery - July 24, 2019 Category: Surgery Authors: Arzoo Orfany, Carlos Gal án Arriola, Ilias P. Doulamis, Alvise Guariento, Giovanna Ramirez-Barbieri, Kamila Moskowitzova, Borami Shin, David Blitzer, Caitlyn Rogers, Pedro J. del Nido, James D. McCully Source Type: research