Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury.

Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury. Am J Physiol Renal Physiol. 2019 Jul 24;: Authors: Ma S, Zhang Y, He K, Wang P, Wang D Abstract Macrophage-mediated inflammation plays a critical role in hypertensive kidney disease. Here we investigated the role of transient receptor potential ankyrin 1 (TRPA1), a sensor of inflammation, in angiotensin (Ang) II-induced renal injury. Subcutaneous infusion of Ang II (600ng/min/kg) for 28 days was used to induce hypertension and renal injury in mice. Results showed that Ang II-induced hypertensive mice have decreased renal Trpa1 expression (P
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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ConclusionsIn this high-risk low-income cohort, contributions of risk factors to HF varied, particularly by race. To reduce the population burden of HF, interventions tailored for specific race and sex groups may be warranted.Graphical abstract
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: December 2019Source: Global Heart, Volume 14, Issue 4Author(s): Ruth Webster, Gary Parker, Stephane Heritier, Rohina Joshi, Karen Yeates, Patricio Lopez-Jaramillo, J. Jaime Miranda, Brian Oldenburg, Bruce Ovbiagele, Mayowa Owolabi, David Peiris, Devarsetty Praveen, Abdul Salam, Jon-David Schwalm, K.R. Thankappan, Nihal Thomas, Sheldon Tobe, Rajesh Vedanthan
Source: Global Heart - Category: Cardiology Source Type: research
This study sought to evaluate the feasibility and the overall results of a hypertension control program, based mainly on a network of community nonprofessional health promoters, in the poor rural region of Borbon (Ecuador).MethodsThis is a prospective cohort study describing the results of a program of hypertension diagnosis, treatment and follow-up from 2004 to 2015 in the area, carried out mainly by the health promoters.ResultsThe number of hypertensive patients identified and followed over the years increased from 1,024 in 2004 to 1,733 in 2015. The percentage of patients with no visits during a year was reduced to
Source: Global Heart - Category: Cardiology Source Type: research
Objective We aimed to compare the demographic, laboratory, and ambulatory blood pressure monitoring (ABPM) parameters of patients with masked hypertension (MHT), define factors predicting MHT, and determine the ABPM parameters affecting left ventricular mass index (LVMI) in obese youth. Methods Data of obese patients were evaluated retrospectively. Patients with ambulatory hypertension (AHT), white-coat hypertension (WCHT), MHT, or normotension (NT) were determined. Demographic and laboratory findings, office and ABPM measurements, blood pressure variability (BPV), and heart rate variability (HRV) were compared betwee...
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophysiology Source Type: research
Background: Obesity is closely related to many chronic diseases and metabolic risk factors. The present study examined the relationship of obesity-related indices to blood pressure (BP) and fasting plasma glucose (FPG) among young Chinese men. Methods: A total of 1193 male college students aged 18–22 years participated in the study. Height, weight, waist circumference (WC), body mass index (BMI), waist-to-height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and FPG were measured. High BP was defined as SBP ≥140 mmHg and/or DBP ≥90 mmHg. Impaired fasting glucose (IFG) was defin...
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophysiology Source Type: research
In conclusion, Transtek TMB-1776 has passed all phases of ESH-IP 2010 and is suitable for self/home blood pressure measurement of adults.
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Devices and Technology Source Type: research
ConclusionsREDUCE LAP-HF II is designed to evaluate the clinical efficacy of the IASD device in patients with symptomatic HF with elevated LA pressure and LVEF≥40%.
Source: American Heart Journal - Category: Cardiology Source Type: research
This study measured stimulus-evoked brain tissue oxygenation changes in a mouse model of Alzheimer disease (AD) and further explored the influence of exercise and angiotensin II-induced hypertension on these changes. In vivo two-photon phosphorescence lifetime microscopy was used to investigate local changes in brain tissue oxygenation following whisker stimulation. During rest periods, PO2 values close to the arteriolar wall were lower in the AD groups and the PO2 spatial decay as a function of distance to arteriole was increased by hypertension. During stimulation, tissue PO2 response had a similar spatial dependence acr...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Authors: Grobelna MK, Strauss E, KrasiƄski Z Abstract Lately there are many new, promising low-density lipoprotein cholesterol reducing therapies with PCSK9 inhibitors. We performed selected sampling of the publications in PubMed and made a review according to selected keywords. It summarizes the effect of PCSK9 on vascular aging, directly associated with lipid and glucose metabolism, chronic inflammation, atherosclerosis and hypertension. Serum level of PCSK9 is different in patients affected by certain illnesses (whose risk increases with age) than in healthy individuals. The same could be observed in the case of c...
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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