EBV –Associated Lymphoproliferative Disorders

Although about 90% of the world ’s population is infected by EBV only a small subset of the related infections result in neoplastic transformation. EBV is a versatile oncogenic agent involved in a multitude of hematopoietic, epithelial, and mesenchymal neoplasms, but the precise role of EBV in the pathogenesis of many of the ass ociated lymphoid/histiocytic proliferations remains hypothetical or not completely understood. Additional studies and use of evolving technologies such as high-throughput next-generation sequencing may help address this knowledge gap and may lead to enhanced diagnostic assessment and the developm ent of potential therapeutic interventions.

Source: Surgical Pathology Clinics - July 26, 2019 Category: Pathology Authors: Sherif A. Rezk, Lawrence M. Weiss Source Type: research