The BRCA2 gene also raises the risk of childhood non-Hodgkin's lymphoma, study finds 

A new study from St Jude Children's Research Hospital has found that about two percent of childhood survivors of non-Hodgkin's lymphoma had inherited mutation of the BRCA2 gene.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Unfortunately, the word ”Group” is missed in the article title of the original publication. It has been corrected by this erratum.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Abstract Gastrointestinal (GI) diffuse large B-cell lymphoma (DLBCL) is one of the frequently reported histologic subtypes of non-Hodgkin lymphoma (NHL) that occur in the GI tract. However, the presentation of quite different clinical manifestations, morphologic characteristics, immunophenotypes, and molecular biologic features is challenging for its diagnosis. Herein, we describe a rare case of primary colorectal DLBCL that occurred in a 59-year-old immunocompetent Chinese female who attended our respiratory clinic for the third time with an asymptomatic pleural effusion and pleural thickening. In her clinical se...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
ConclusionsPola PK was well characterized with no clinically meaningful DDIs with R/G-CHP. Findings are consistent with previous studies of pola  + R/G, and support pola + R/G-CHP use in previously untreated diffuse large B-cell lymphoma.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Conditions:   Non Hodgkin Lymphoma;   Acute Lymphoblastic Leukemia;   Diffuse Large B Cell Lymphoma;   Primary Mediastinal Large B Cell Lymphoma;   Mantle Cell Lymphoma;   Follicular Lymphoma Interventions:   Drug: TC-110 T Cells;   Drug: Fludarabine;   Drug: Cyclophosphamide Sponsor:   TCR2 Therapeutics Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Non Hodgkin Lymphoma;   Acute Lymphoblastic Leukemia;   Diffuse Large B Cell Lymphoma;   Primary Mediastinal Large B Cell Lymphoma;   Mantle Cell Lymphoma;   Follicular Lymphoma Interventions:   Drug: TC-110 T Cells;   Drug: Fludarabine;   Drug: Cyclophosphamide Sponsor:   TCR2 Therapeutics Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Non Hodgkin Lymphoma;   Acute Lymphoblastic Leukemia;   Diffuse Large B Cell Lymphoma;   Primary Mediastinal Large B Cell Lymphoma;   Mantle Cell Lymphoma;   Follicular Lymphoma Interventions:   Drug: TC-110 T Cells;   Drug: Fludarabine;   Drug: Cyclophosphamide Sponsor:   TCR2 Therapeutics Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Non Hodgkin Lymphoma;   Acute Lymphoblastic Leukemia;   Diffuse Large B Cell Lymphoma;   Primary Mediastinal Large B Cell Lymphoma;   Mantle Cell Lymphoma;   Follicular Lymphoma Interventions:   Drug: TC-110 T Cells;   Drug: Fludarabine;   Drug: Cyclophosphamide Sponsor:   TCR2 Therapeutics Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Treatment outcomes in pediatric lymphoma have improved substantially over the past 2 decades; however, the prognosis for patients with high risk or relapsed disease remains poor. We evaluated outcomes of high-dose chemotherapy (HDC) and autologous stem cell transplantation (auto-SCT) in 56 pediatric lymphoma patients. Patients received nitrosourea (51 BCNU; 5 ACNU), etoposide, and cyclophosphamide (BEC; AEC). Median age at HDC/auto-SCT was 12 years (range 2-17 years). Forty-four patients underwent HDC/auto-SCT because they did not achieve complete remission after induction chemotherapy. Eight pa...
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research
Authors: Fratoni S, Zanelli M, Zizzo M, Sanguedolce F, Aimola V, Cerrone G, Ricci L, Filosa A, Martino G, Fara AM, Annessi V, Soriano A, Ascani S Abstract Follicular lymphoma is a neoplasm derived from follicle center B cells, typically both centrocytes and centroblasts, in variable proportions according to the lymphoma grading. The pattern of growth may be entirely follicular, follicular and diffuse and rarely completely diffuse. It represents the second most common non-Hodgkin lymphoma, after diffuse large B-cell lymphoma and it is the most common low-grade mature B-cell lymphoma in Western countries. In the majo...
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
Precursor B-cell lymphoblastic lymphoma (PBLL) is a rare subtype of non-Hodgkin lymphoma originating from B-cell precursors. PBLL, as a solitary mass lesion affecting the central nervous system without leukemic disease at presentation, is quite uncommon. Here we report a rare PBLL case with Philadelphia chromosome positivity. The 44-year-old male presented a solitary bulky mass primarily involving the left frontotemporal lobes and extended into the infratemporal fossa. Pretreatment PET/CT imaging showed avid 18F-fluorodeoxyglucose (18F-FDG) uptake of the lesion. By aggressive chemotherapy and imatinib maintenance treatment...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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