Cerebrospinal Fluid Findings in Patients With Autoimmune Encephalitis —A Systematic Analysis

Autoimmune encephalitides (AIE) comprise a group of inflammatory diseases of the central nervous system (CNS), which can be further characterized by the presence of different antineuronal antibodies. Recently, a clinical approach for diagnostic criteria for the suspected diagnosis of AIE as well as definitive AIE were proposed. These are intended to guide physicians when to order the antineuronal antibody testing and/or facilitate early diagnosis even prior to the availability of the specific disease-confirming test results to facilitate prompt treatment. These diagnostic criteria also include the results of basic cerebrospinal fluid (CSF) analysis. However, the different antibody-defined AIE subtypes might be highly distinct with regard to their immune pathophysiology, e.g., the predominance of specific IgG subclasses, IgG1 or IgG4, or frequency of paraneoplastic compared to idiopathic origin. Thus, it is conceivable that the results of basic CSF analysis might also be very different. However, this has not been explored systematically. Here, we systematically reviewed the literature about the ten most important AIE subtypes, AIE with antibodies against NMDA, AMPA, glycine, GABAA and GABAB receptors as well as DPPX, CASPR2, LGI1, IgLON5 or glutamate decarboxylase (GAD), with respect to the reported basic CSF findings comprising CSF leukocyte count, total protein and the presence of oligoclonal bands (OCB) restricted to the CSF as a sensitive measure for intrathecal IgG synth...
Source: Frontiers in Neurology - Category: Neurology Source Type: research