Cytotoxic diterpenoid alkaloid from Aconitum japonicum subsp. subcuneatum

AbstractWe explored new cytotoxic C19-diterpenoid alkaloid, lipojesaconitine(1), from rhizoma ofAconitum japonicum Thunb. subsp.subcuneatum (Nakai) Kadota. Two additional non-cytotoxic new C19-diterpenoid alkaloids, 10-hydroxychasmanine(2) and 3-hydroxykaracoline(3), together with eight known C19- and C20-diterpenoid alkaloids (4 −11) were also isolated. Their structures were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). Six known diterpenoid alkaloids, foresticine (5), neolinine (6), aconicarchamine A (7), 9-hydroxynominine (8), kobusine (9), and torokonine (10), were isolated for the first time fromA. japonicum subsp.subcuneatum. Alkaloid1 showed cytotoxicity with IC50 values ranging from 6.0 to 7.3  µM against four human tumor cell lines, except a multidrug-resistant subline, suggesting that1 was likely exported by P-glycoprotein.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research

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