A Closer Look at the Data Regarding Suicidal Ideation and Behavior in Psoriasis Patients: The Case of Brodalumab

A Closer Look at the Data Regarding Suicidal Ideation and Behavior in Psoriasis Patients: The Case of Brodalumab Skin Therapy Lett. 2019 Jul;24(4):1-4 Authors: Rodriguez-Bolanos F, Gooderham M, Papp K Abstract The interleukin (IL)-17 inhibitors have proven to be highly effective in the treatment of psoriasis. The most recently approved agent, brodalumab, had few cases of suicidal behavior, including completed suicide, in the phase 3 clinical program leading both the US FDA and Health Canada to add a boxed warning to its label. This raises the importance of identifying the psychiatric comorbidities associated with psoriasis. It is also necessary to critically examine the data from the brodalumab clinical trial program to determine whether there is enough information to establish causality and whether other factors, other than the drug, could be playing a role. PMID: 31339678 [PubMed - as supplied by publisher]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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Suicidal ideation has been reported in psoriasis patients treated with brodalumab, which led to a black box warning. Is there enough evidence to establish causality, or are other factors involved?Skin Therapy Letter
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
AbstractBackgroundChronic inflammatory diseases such as psoriasis require treatment options that maintain efficacy and tolerability during extended treatment.ObjectiveThe aim of the study was to assess the long-term efficacy and safety of brodalumab, a fully human anti-interleukin-17 receptor A monoclonal antibody, in patients with moderate-to-severe plaque psoriasis.MethodsPatients who completed a 12-week, phase II, dose-ranging clinical trial received brodalumab 210  mg every 2 weeks in an open-label extension study. Efficacy was assessed by static physician’s global assessment (sPGA) and psoriasis area a...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
CONCLUSION: Singh et al. concluded that patients with psoriasis have a significantly higher risk of suicidal ideation, suicide attempts, and completed suicides, while Chi et al concluded that the available limited, very low-quality evidence does not support the notion of an association between psoriasis on the one hand, and suicide, suicidal ideation and attempts on the other. This article is protected by copyright. All rights reserved. PMID: 31074832 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
CONCLUSION: Psychiatric and physical disorders carried greatly increased risks and numbers of suicides in South Korea. Schizophrenia was the strongest risk factor, especially 35-65 years, and depression was the most common in suicide victims among ICD-10 disorders in South Korea. PMID: 31042694 [PubMed]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
To the Editor: Significantly increased risks for depression and suicidality have been found in psoriasis patients,1 and psoriasis has been independently associated with major depression.2 Therefore, it is important to be able to identify depression and suicidal ideation and behavior (SIB) among psoriasis patients. Standardized screening tools, such as the Patient Health Questionnaire-2 (PHQ-2), enable rapid identification of depression and SIB within minutes, making screening feasible, efficient, and effective in the outpatient setting.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
This study examined the risks of a range of adverse events in a large cohort of patients prescribed long‐term opioids using the UK Clinical Practice Research Datalink.MethodsPatients with musculoskeletal conditions starting a new long ‐term opioid episode (defined as ≥3 opioid prescriptions within 90 days) between 2002‐2012 were included. Primary outcomes: major trauma and intentional overdose (any). Secondary outcomes: addiction (any), falls, accidental poisoning, attempted suicide/self‐harm, gastrointestinal pathology a nd bleeding, and iron deficiency anaemia. ‘Control’ outcomes (unrelated to opio...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Psoriasis is a chronic systemic inflammatory skin disease, which has been associated with an increased risk of numerous medical and psychiatric comorbidities, including suicidality. Suicidality, which can be divided into the categories of suicidal ideation...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
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