Shingrix for Herpes Zoster: A Review

Shingrix for Herpes Zoster: A Review Skin Therapy Lett. 2019 Jul;24(4):5-7 Authors: Shah RA, Limmer AL, Nwannunu CE, Patel RR, Mui UN, Tyring SK Abstract Herpes zoster (HZ), also known as shingles, results from reactivation of the latent varicella-zoster virus (VZV), which commonly causes chickenpox in childhood. Greater than 90% of adults are infected with this virus, putting them at risk for reactivation. HZ presents as a painful, vesicular rash distributed in a unilateral and dermatomal pattern along dorsal root or cranial nerve ganglia. The rash often presents with prodromal symptoms and progresses to include clear vesicular clusters, evolving through stages of pustulation, ulceration, and crusting. HZ therapy currently involves the use of antiviral agents and pain management; however, HZ prophylaxis has been strongly recommended in older adults through vaccination with a live attenuated vaccine, Zostavax®. A new recombinant subunit vaccine, HZ/su (Shingrix®), is the subject of this review. In clinical trials, HZ/su demonstrated an overall vaccine efficacy of 97.2% among participants 50 years of age or older, indicating a significantly reduced risk of HZ in these individuals. Shingrix® was approved by the US FDA in October 2017 as HZ prophylaxis. PMID: 31339679 [PubMed - as supplied by publisher]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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Abstract Herpes zoster (HZ), commonly called shingles, it is a distinctive syndrome caused by reactivation of varicella zoster virus (VZV). A better understanding of the biological characteristics of HZ patients can help develop new targeted therapies to improve the prognosis. High-throughput proteomics technology can deeply study the molecular changes in the development and progression of HZ disease and integrate different levels of information, this is important to help make clinical decisions. Circulating blood contains a lot of biological information, we conducted a proteomics study of patient plasma, hoping t...
Source: Journal of Proteomics - Category: Biochemistry Authors: Tags: J Proteomics Source Type: research
Herpes zoster (HZ) and its main complication, postherpetic neuralgia (PHN), constitute an important health problem, reducing the quality of life of patients, and increasing healthcare costs (1). Many patients with PHN develop severe physical, occupational and social disabilities because of enduring pain (2). HZ or shingles is caused by the reactivation of the Varicella Zoster Virus (VZV), which remains latent in sensory nerve ganglia following the primary infection (chickenpox). This reactivation causes a localized eruption of vesicular lesions and the presence of pain and inflammation of the affected nerve root (3).
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Follow me on Twitter @RobShmerling Perhaps you heard the news recently that Lin-Manuel Miranda has shingles. Headlines announced this in a variety of ways: Hamilton creator Lin-Manuel Miranda is suffering from shingles (NY DailyNews) Lin-Manuel Miranda has shingles; must be quarantined from his baby ( Lin-Manuel Miranda has shingles, regrets joke about blurred vision (CBS News). Without more information, these headlines might leave you wondering: is this a serious condition? Is it dangerous for children? Can it lead to blindness? What is shingles? The term “shingles” refers to a painful rash caused ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Skin and Hair Care Vaccines Source Type: blogs
View Original Article Here: How Long Does Shingles Last In The Elderly? Shingles is a viral infection that follows a varicella-zoster infection, although it can take decades for symptoms of the secondary disease to emerge. The condition presents as a painful and blistering rash, but it is not life-threatening. According to the Center for Disease Control, there are nearly one million cases in the United States each year, and almost half of those cases are in older adults over age 60. Some people only see one instance of the illness, while others have recurring symptoms, but 30 percent of Americans will develop shingles at s...
Source: Shield My Senior - Category: Geriatrics Authors: Tags: Senior Safety Source Type: blogs
We present a case of foraminal disk extrusion that resulted in radicular pain in a dermatomal distribution. The resultant inflammatory response around the dorsal root ganglion triggered an episode of shingles, which elegantly highlights the pathophysiology of this condition at a gross anatomic level.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Clinical Images Source Type: research
By Amanda MacMillan A few weeks after my 34th birthday, my husband and I went for a Saturday hike — a weekly ritual we’d started after moving to New York State’s Catskill Mountains region a few months earlier. I’d been feeling a bit under the weather, and I hoped the fresh autumn air would do me good. It didn’t. Later that night, I had chills and my skin felt strangely sensitive, like when you’re coming down with the flu. On top of that, it felt like I had pulled a muscle in my back or chest; when I breathed or stretched certain ways, I’d get shooting pains across my body. I blamed...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
In this study the authors demonstrate that, as in many other cases, the methodology of delivery matters just as much as the details of the cells used: Retinal and macular degenerative diseases affect millions of people worldwide. Similar to other neurodegenerative diseases, there are no effective treatments that can stop retinal degeneration or restore degenerative retina. Recent advances in stem cell technology led to development of novel cell-based therapies, some are already in phase I/II clinical trials. Studies from our group and others suggest that human bone marrow-derived mesenchymal stem cells (hBM-MSC) m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Varicella Zoster Virus (VZV) is a common skin-tropic virus. Primary infection with VZV manifests with a generalised skin blistering rash called chickenpox, while secondary infection presents with localised nerve pain and rash (herpes zoster, or Shingles). VZV infection can be life-threatening in immunocompromised children. In VZV- infected skin the ubiquitin-ligase MDM2 was upregulated and keratin 10 (KRT10) was reduced. We show that MDM2 binds KRT10 in vitro and also in VZV-infected skin explants.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Inflammation & Microbiology Source Type: research
Vaccine helps prevent shingles in older adults for up to three years The varicella zoster virus causes chickenpox and can remain dormant inside nerve cells. After many years, it can reactivate and travel through the nerve to the skin, causing itching, numbness, tingling or local pain, and then blisters along the nerve path. These blisters are often accompanied with inflammation of the nerves and severe pain, which can affect quality of life. This is called herpes zoster or shingles. It affects people with low immunity such as older people. There are about 5.22 episodes of shingles for every 1000 older people. This is ...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
If you had chickenpox as a child, the virus that caused it can re-emerge later in life — out of the blue — to cause shingles. This condition, also known as herpes zoster, consists of a rash on one side of the body, often accompanied by excruciating pain. The rash typically goes away in about a month, but in some people, the pain lingers for weeks, months, or even years. This chronic pain is called post-herpetic neuralgia. The virus that causes chickenpox, known as varicella-zoster, doesn’t necessarily disappear from the body after the chickenpox rash fades away. Instead, the virus can go into hiding, taki...
Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Vaccines HZ/su shingles varicella-zoster Zostavax Source Type: news
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