New promising avenue for the simvastatin combination with residronate, strontium ranelate and raloxifene in experimentally-induced osteoporosis

Publication date: Available online 24 July 2019Source: The Egyptian RheumatologistAuthor(s): Amira K. Khalifa, Sohier A. Diab, Ghada M. Hashem, Essam F. Alalkamy, Mira F. YacoubAbstractAim of the workThis is the first experimental study to assess the possible synergistic effects of simvastatin combination with residronate, strontium ranelate and raloxifene on glucocorticoid induced osteoporosis (GIO) in female albino rats.Materials and methods48 mature healthy female albino rats were randomly allocated into 6 main groups (8 rats /group) and received all drugs daily orally for 6 weeks. (G1) negative control group; (G2) osteoporotic group that received prednisolone at 15 mg/kg/day; (G3) prednisolone + 10 mg/kg/day simvastatin; (G4) received prednisolone + simvastatin + residronate 1 mg/kg/day; (G5) prednisolone + simvastatin + strontium ranelate 600 mg/kg/day; (G6) prednisolone + simvastatin + raloxifene at 1.25 mg/kg/day. After 6 weeks, mean arterial blood pressure (MAP), ejection fraction and left ventricular diameter were assessed. Bone histomorphometry, serum level of bone specific alkaline phosphatase (BsALP), osteocalcin (OCN), calcium, phosphorus, AST and ALT and bone mineral assessment by DEXA.ResultsSimvastatin combined regimens-treated groups exerted significant marked amelioration of osteoporotic changes by achieving the highest histopathological score, bone mineral density by DEXA scan, increase in serum Ca, OCN and decrease...
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research

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Authors: Zamoscinska M, Faber IR, Büsch D Abstract Clinical Scenario: Reduced bone mineral density (BMD) is a serious condition in older adults. The mild form, osteopenia, is often a precursor of osteoporosis. Osteoporosis is a pathological condition and a global health problem as it is one of the most common diseases in developed countries. Finding solutions for prevention and therapy should be prioritized. Therefore, the critically appraised topic focuses on strength training as a treatment to counteract a further decline in BMD in older adults. Clinical Question: Is strength training beneficial in increasin...
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
Journal of Women's Health, Ahead of Print.
Source: Journal of Women - Category: OBGYN Authors: Source Type: research
Abstract Danio rerio (zebrafish) is an elective model organism for the study of vertebrate development because of its high degree of homology with human genes and organs, including bone. Zebrafish embryos, because of the optical clarity, small size, and fast development, can be easily used in large-scale mutagenesis experiments to isolate mutants with developmental skeletal defects and in high-throughput screenings to find new chemical compounds for the ability to revert the pathological phenotype. On the other hand, the adult zebrafish represents another powerful resource for pathogenic and therapeutic studies ab...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
AbstractSummaryHypocalcemia was reported at low rates (0.05 –1.7%) in denosumab-treated postmenopausal women with osteoporosis. This real-life study shows a 7.4% rate of denosumab-induced hypocalcemia in community-dwelling osteoporotic men and women. Pretreatment serum calcium and creatinine levels are major predictors for this complication. Serum-calcium monitoring may help to identify and prevent severe hypocalcemia.PurposeRCTs have reported a 0.05 –1.7% rate of hypocalcemia in denosumab-treated postmenopausal women with osteoporosis, but long-term real-life data are lacking. We assessed the rate of hypocalce...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Condition:   Atrial Fibrillation Interventions:   Drug: warfarin;   Drug: apixaban Sponsor:   Pfizer Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
ConclusionThese modified recommendations provide guidance for rheumatologists, radiologists and healthcare professionals on timely diagnosis of axSpA and disease management with appropriate imaging modalities.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: REVIEW Source Type: research
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Abstract Cuscuta chinensis Lam. (Convolvulaceae) is an important herbal medicine widely used to improve sexual function, treat osteoporosis, and prevent aging, and has been reported to exhibit anti-osteoporotic effects in vitro. However, the activity of Cuscuta chinensis Lam. on glucocorticoid-induced osteoporosis still remains unclear. The present study aimed to assess the protective effect and the underlying mechanism of action of Cuscuta chinensis extract (CCE) against glucocorticoid-induced osteoporosis in vivo. Sprague-Dawley rats were randomly divided into four groups as follows: control group, osteoporosis ...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
Condition:   Osteoporosis Intervention:   Behavioral: Nutrition education intervention about osteoporosis and calcium Sponsors:   Texas Tech University;   Hanoi University of Pharmacy;   Vietnam National Institute of Nutrition Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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