High prevalence and disease correlation of autoantibodies against p40 encoded by long interspersed nuclear elements (LINE ‐1) in systemic lupus erythematosus

ConclusionsAutoantibodies reacting with LINE ‐1 p40 characterize a population of SLE patients with severe and active disease. These autoantibodies may represent an early immune response against LINE‐1 p40 that does not yet by itself imply clinically significant autoimmunity, but may represent an early, and still reversible, step towards SL E pathogenesis.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatology - July 23, 2019 Category: Rheumatology Authors: Victoria Carter, John LaCava, Martin S. Taylor, Shu Ying Liang, Cecilia Mustelin, Kennedy C. Ukadike, Anders Bengtsson, Christian Lood, Tomas Mustelin Tags: Full Length Source Type: research