Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors

Conditions:   Brain Tumor;   Brain Tumor, Recurrent;   Brain Tumor, Refractory;   Brain Tumor, Pediatric;   Medulloblastoma;   Medulloblastoma Recurrent;   Medulloblastoma, Non-WNT/Non-SHH;   Medulloblastoma, Non-WNT/Non-SHH, Group 3;   Medulloblastoma, Non-WNT/Non-SHH, Group 4;   Brai n Cancer;   CNS Cancer;   CNS Tumor;   CNS Neoplasm Interventions:   Drug: Prexasertib;   Drug: Cyclophosphamide;   Drug: Gemcitabine;   Biological: filgrastim;   Biological: peg-filgrastim Sponsors:   St. Jude Children's Research Hospital;   Eli Lilly and Company Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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In conclusion, our results of bioinformatic analysis, in vitro and in vivo functional analysis suggested that REST may serve as a promoter of metastasis in pancreatic cancer. Introduction Pancreatic cancer, ranked fourth in cancer-related mortality, is characterized by its rapid progression and early metastasis (1). Patients are hardly cured by surgical resection due to the existing local invasion and distant metastasis (2). Elevating the overall survival rate for pancreatic cancer requires further elucidation of the underlying molecular mechanism of its metastasis. Epithelial-mesenchymal transition (EMT), especially...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, we have shown the safety and efficacy of Vemurafenib in a pediatric patient with DS affected by PXA. Ethics Statement This study was carried out in accordance with the recommendations of the Internal Review Board of the Bambino Gesù Children's Hospital with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Internal Review Board of the Bambino Gesù Children's Hospital. Informed Consent The authors declare that written informed consent was obtained from the pat...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Multidisciplinary Web conference for AYAs is feasible and increases the inclusion rate in protocols. It should be developed further. PMID: 27866682 [PubMed - as supplied by publisher]
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: Tags: Bull Cancer Source Type: research
Conditions:   Medulloblastoma, Childhood, Recurrent;   Atypical Teratoid/Rhabdoid Tumor;   Medulloblastoma Recurrent Interventions:   Biological: Modified Measles Virus;   Biological: Modified Measles Virus Lumbar Puncture Sponsors:   University of California, San Francisco;   No More Kids With Cancer;   The Matthew Larson Foundation for Pediatric Brain Tumors;   Vyriad, Inc.;   Mayo Clinic Not yet recruiting - verified November 2016
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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