Metabolic Disorders and Male Hypogonadotropic Hypogonadism
Several studies highlight that testosterone deficiency is associated and predicts increased risk of developing metabolic disorders, and, that it is highly prevalent in obesity, metabolic syndrome and type-2 diabetes mellitus. Models of gonadotropin releasing hormone deficiency and androgen deprivation in patients with prostate cancer suggest that hypogonadotropic hypogonadism might contribute to onset or further worsen metabolic conditions by means of increased fat mass and insulin resistance. Nevertheless, in functional hypogonadism, such as late onset hypogonadism, the relationship between hypogonadotropic hypogonadism and metabolic disorders is bidirectional, and a vicious circle between the two components has been documented. The mechanisms underlying the crosstalk between testosterone deficiency and metabolic disorders include increased visceral adipose tissue and insulin resistance, leading to development of metabolic disorders, which in turn contribute to a further reduction of testosterone, determined by insulin resistance- and possibly pro-inflammatory cytokine-mediated, decrease of sex hormone binding globulin, resulting in increased free testosterone available for aromatization in visceral adipose tissue, a subsequent decrease in free testosterone, due to the excess of visceral adipose tissue and aromatization, and reduced gonadotropin secretion induced by estradiol, inflammatory mediators, leptin resistance, and insulin resistance, with determination of substantia...
DNA changes in a common type of breast cancer cell may be linked to hormone therapy resistance, according to a study published inNature Communications.Science Daily
We have vacancies for the Editor-in-Chief positions on the Editorial Boards of Endocrine Connections and Endocrine-Related Cancer.Endocrine Connections is jointly owned by the Society for Endocrinology and the European Society of Endocrinology. It is an open access journal offering authors the highest possible visibility for their work and stimulating cross-discipline collaboration. Read the full job description.Endocrine-Related Cancer is the official flagship journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology, Endocrine Society of Australia...
Two Clinical Nurse Specialist opportunities are available to contribute towards the provision of excellent patient care within our Endocrinology and Diabetes Service.One post will be for our Queen Elizabeth Hospital (QEHB) site and the other for our Heartlands, Good Hope and Solihull Hospital site (HGS). Successful candidates will join a team of experienced specialist nurses in a tertiary Endocrine referral centre and will be given full structured training and supervision to develop their skills in Endocrinology.Application deadline is2 February 2020. Visit www.jobs.nhs.uk for full details and to apply.
Researchers reports an over 50% drop in overall death rates among people with diabetes living in Hong Kong from 2001-2016; younger people with diabetes less likely to experience improvement in survival, however.Medscape Medical News
Conclusion The current level of awareness for clinical trials of cancer patients in our hospital was relatively low, even in patients who had atte nded clinical trials before. It’s necessary to improve patients’ awareness of clinical trial by promoting harmony relationship between patients and doctors, as well as by enhancing related propagation. Strengthening the adequacy and efficacy of informed consent in clinical trials also needs to b e achieved in the future. DOI: 10.3779/j.issn.1009-3419.2020.01.02
Conclusion T4 stage patients had worse survival in N2 group. To get a more precisely stratification, skip metastasis and number of involved lymph node stations should be considered in future N stage classification. DOI: 10.3779/j.issn.1009-3419.2020.01.03
Conclusion The expression of TRIM59 is closely related to the prognosis of NSCLC patients, and it is an independent risk factor for NSCLC patients. DOI: 10.3779/j.issn.1009-3419.2020.01.04
This study mainly explores the relationship between the ASPM expression of lung adenocarcinoma and the development and prognosis of lung cancer. The aim of this study was to investigate the relationship between the expression of abnormal spindle-like microcephaly-associated protein (ASPM) in lung adenocarcinoma and the development and prognosis in lung cancer. Methods A total of 90 cases of lung adenocarcinoma tissue specimens and 90 cases of benign pulmonary lesions were collected, the expression of ASPM was detected by immunohistochemical technique, and the expression of ASPM in 12 pairs of tissues was detected by real-t...
Conclusion It was safety to discontinued oral antiplatelet agents before operation, with no MACE and death in perioperative period. DOI: 10.3779/j.issn.1009-3419.2020.01.06