Use of Dapagliflozin in the Management of Type 2 Diabetes Mellitus: A Real-World Evidence Study in Indian Patients (FOREFRONT)
Diabetes Technology&Therapeutics,Volume 21, Issue 8, Page 415-422, August 2019.
ConclusionsLinagliptin showed cardiovascular and renal safety in Asian patients with T2DM and established CVD with albuminuria and/or kidney disease.
Publication date: Available online 21 October 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Huiwen Ren, Ying Shao, Can Wu, Xiaoyu Ma, Chuan Lv, Qiuyue WangAbstractMetformin, as the basic pharmacological therapy and the first preventive drug in type 2 diabetes mellitus (T2DM), is proved to have potential protection in diabetic kidney disease (DKD). Here, we established a diabetic rat model induced by high-fat diet and low dose streptozotocin, and high glucose cultured rat mesangial cells (RMCs) pre-treated with metformin or transfected with AMPK, SIRT1 and FoxO1 small interfering RNA, and detected oxidative str...
A 65-year-old man was admitted with slurred speech of acute onset. He had a past medical history of type 2 diabetes mellitus, hypertension and bipolar disorder on metformin, amlodipine and lithium. He had difficulty pronouncing simple words and was speaking incoherently. He seemed confused and had difficulty walking. There had been no recent falls, head trauma or alcohol ingestion.
A 52 year old man presented with confusion. He was febrile with evidence of circulatory compromise and delirium. He was known to have type 2 diabetes mellitus of more than 10 years duration and had been prescribed insulin for more than 5 years. At the time of admission severe diabetic ketoacidosis was diagnosed and a treatment with intravenous fluids, insulin and broad spectrum antibiotics was commenced (Table). Despite aggressive treatment, the patient remained delirious with raised inflammatory markers.
Type 2 diabetes mellitus (T2DM) is associated with hypofibrinolysis and increased factor XIII-mediated α2-antiplasmin incorporation into the fibrin clot. It is unclear whether there are sex-related differences in α2-antiplasmin incorporation in relation to impaired clot lysis in T2DM.
Type 2 diabetes mellitus (T2DM) leads to exaggerated cardiovascular responses to exercise, in part due to an exaggerated exercise pressor reflex. Accumulating data suggest excessive oxidative stress contributes to an exaggerated exercise pressor reflex in cardiovascular-related diseases. Excessive oxidative stress is also a primary underlying mechanism for the development and progression of T2DM. However, whether oxidative stress plays a role in mediating the exaggerated exercise pressor reflex in T2DM is not known.
Metabolic Syndrome and Related Disorders, Ahead of Print.
Conclusions: The models developed using insurance claims data could reliably predict the risk of MACRO in patients with T2DM and enabled patients at higher-risk of DKD to be identified in the absence of baseline diabetic nephropathy, CKD, or proteinuria. These models could help establish strategies to reduce the risk of MACRO in T2DM patients. PMID: 31625766 [PubMed - as supplied by publisher]
ConclusionsFindings from observational studies support current dietary guidelines for the prevention of T2DM. Further dietary intervention studies are needed to confirm whether or not dietary modification following a GDM pregnancy reduces women's risk of developing T2DM.