In-Depth, Proteomic Analysis of Nasal Secretions from Patients With Chronic Rhinosinusitis and Nasal Polyps.

CONCLUSIONS: Collection of nasal secretions on the filter paper is a practical and non-invasive method for in-depth study of nasal proteomics. Our proteomic signatures also support that Asian NPs could be characterized as non-eosinophilic inflammation features. Therefore, the proteomic profiling of nasal secretions from CRS patients may enhance our understanding of CRS endotypes. PMID: 31332980 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

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BackgroundCentral compartment atopic disease (CCAD) is a recently described variant of chronic rhinosinusitis with nasal polyp (CRSwNP) associated with inhalant allergy. An association with asthma was noted to be uncommon within our clinical practice. The purpose of this study was to determine allergy and asthma prevalence in CCAD and other CRSwNP subtypes.MethodsA retrospective analysis at a tertiary care institution was performed over the period from 2015 to 2019. CRSwNP was grouped into the following subtypes: allergic fungal rhinosinusitis (AFRS); aspirin ‐exacerbated respiratory disease (AERD); CCAD; and CRSwNP not ...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Personalized management of a disease based on patient-specific pathophysiology is 1 of the pillars of precision medicine. The management of aspirin-exacerbated respiratory disease (AERD), a disease defined in part by chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma, is a unique opportunity to implement precision medicine. Driven by dysregulated arachidonic acid metabolism, AERD is characterized by overproduction of pro-inflammatory cysteinyl leukotrienes over anti-inflammatory prostaglandins, leading to eosinophilic and type 2 T-helper (Th2) inflammatory response in the airway mucosa.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
CONCLUSIONS: Elevated expression of NF-κB- and NF-κB-associated inflammatory cytokines suggests NF-κB as the key factor for CRSwNPs pathogenesis in Asian patients. Understanding NF-κB-associated mechanisms will provide a deeper insight into CRSwNPs pathogenesis and ultimately improve therapeutic strategies for CRSwNPs. PMID: 31552716 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Establishing a Therapeutic Strategy Targeting NF-κB in Asian Patients with Chronic Rhinosinusitis With Nasal Polyps. Allergy Asthma Immunol Res. 2019 Nov;11(6):757-759 Authors: Kim YH PMID: 31552711 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Capsule Summary: Patients with CRSwNP and asthma show high levels of TATc and TAFI in the nose and sinuses which may contribute to the fibrin deposition in nasal polyps.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Chronic rhinosinusitis is a long-lasting medical condition, usually caused by infection or exposure to irritants, such as allergies, that affects one in seven American adults. Symptoms include nasal obstruction, nasal congestion, nasal drainage, loss of smell and taste, and facial pain and pressure. Some people with chronic rhinosinusitis also develop additional symptoms, such as asthma and nasal polyps, that are exacerbated by underlying allergies. A nasal polyp is a noncancerous tumor that grows from the lining of the nose or sinuses and affects the drainage system of the sinuses. While chronic rhinosinusitis is not a li...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Cold and Flu Drugs and Supplements Ear, nose, and throat Health Source Type: blogs
Publication date: Available online 4 September 2019Source: American Journal of OtolaryngologyAuthor(s): Rosati Davide, Rosato Chiara, Pagliuca Giulio, Cerbelli Bruna, Della Rocca Carlo, Di Cristofano Claudio, Martellucci Salvatore, Gallo AndreaAbstractBackgroundIn last years, many attempts were made to recognize chronic rhinosinusitis with nasal polyps (CRSwNP) phenotypes focusing on identifying relevant key pathogenic molecules. Polyps recurrence rate ranges from 4% to 60%, so it's clear that not all clinical and immunologic factors associated with recurrence are known.ObjectiveWe investigate the inflammatory profile in p...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: September–October 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7Author(s): Claus Bachert, Peter W. Hellings, Joaquim Mullol, Robert M. Naclerio, Jingdong Chao, Nikhil Amin, Annette Grabher, Brian N. Swanson, Jennifer D. Hamilton, Sophie Guillonneau, Christine Taniou, Donghui Zhang, Gianluca Pirozzi, Neil M.H. Graham, Heribert Staudinger, Leda P. Mannent, Asif Khan
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The incidence of chronic rhinosinusitis with nasal polyps has recently increased in Japan and other East Asian countries, and this disease is called eosinophilic chronic sinusitis (ECRS) in Japan. ECRS usually...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Case report Source Type: research
AbstractPurpose of ReviewChronic rhinosinusitis and nasal polyps (CRSwNP) is a common condition that significantly affects patients ’ life. This work aims to provide an up-to-date overview of CRSwNP in older adults, focusing on its aging-related clinical presentations, pathophysiology, and comorbidity associations including asthma.Recent FindingsRecent large population-based studies using nasal endoscopy have shown that CRSwNP is a mostly late-onset disease. Age-related changes in physiologic functions, including nasal epithelial barrier dysfunction, may underlie the incidence and different clinical presentations of ...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
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