The clinical significance of atypical indirect immunofluorescence patterns on primate cerebellum in paraneoplastic antibody screening

ConclusionsAn atypical indirect immunofluorescence pattern on primate cerebellum in the screening for paraneoplastic antibodies has only very minor relevance with respect to paraneoplastic neurological syndromes or any other neurological disease, recommending clinicians to interpret the results of positive screening assays for such antibodies with care.
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research

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Publication date: Available online 16 October 2019Source: Pharmacological ResearchAuthor(s): Siqi Feng, Huan Wang, Jiali Liu, Jiye AA, Fang Zhou, Guangji WangAbstractKetone bodies are traditionally viewed as metabolic substrates in carbohydrate restriction and are applied in the treatment of epilepsy and other neurodegenerative diseases. Recently, people have paid more attention to its application in the treatment for cancers. Compared to normal cells, cancer cells maintain a higher level of reactive oxygen species (ROS) due to the dysfunctional oxidative phosphorylation and they highly rely on glucose for glycolysis and p...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusions The proposed recommendations should serve as a guide for the fitness and health care professional working with cancer survivors. More research is needed to fill remaining gaps in knowledge to better serve cancer survivors, as well as fitness and health care professionals, to improve clinical practice.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: SPECIAL COMMUNICATIONS Source Type: research
Mind-reading exoskeletons, digital tattoos, 3D printed drugs, RFID implants for recreational purposes: mindblowing innovations come to medicine and healthcare almost every single day. We shortlisted some of the greatest ideas and developments that could give us a glimpse into the future of medicine, but we found so many that we had trouble fitting them into one article. Here are the first ten spectacular medical innovations to watch for. 1) Mixed reality opens new ways for medical education Augmented, virtual, and mixed reality are all technologies opening new worlds for the human senses. While the difference between...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine 3d printing artificial food brain-computer interface cyborg digital tattoos drug development exoskeleton gamification google glass health insurance Healthcare Innovation List Medical education medical techn Source Type: blogs
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
DiscussionA common procedure for assessing cognitive and psychobehavioral function is now available in patients with epilepsy undergoing surgical evaluation have been established, they may help to improve the quality of care and the patient experience. This work highlights the need of furthers investigations and the necessity to develop specific tools with normative data.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 16 October 2019Source: Epilepsy &BehaviorAuthor(s): Giada Pauletto, Francesco Bax, Gian Luigi Gigli, Simone Lorenzut, Lorenzo Verriello, Elisa Corazza, Mariarosaria ValenteAbstractAim of the studyThe aim of the study was to evaluate the clinical characteristics of patients with previous stroke (either ischemic or hemorrhagic), who developed status epilepticus (SE) mimicking a stroke relapse.Materials and methodsWe performed a retrospective cohort study of patients brought to hospital by the emergency service between December 2016 and January 2018 with a stroke code as possible candida...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 15 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Theresa Auer, Philipp Schreppel, Thomas Erker, Christoph SchwarzerAbstractEpilepsies represent one of the most common neurological diseases worldwide. They are characterized by recurrent spontaneous seizures with severe impact on a patient’s life. An imbalance in excitatory and inhibitory signalling is considered the main underlying pathophysiological mechanism. Therefore, GABA-mimetic drugs, strengthening the main inhibitory signalling system in the CNS, are frequently used as antiepileptic or anticonvulsant drugs. How...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Psychogenic non-epileptic seizures (PNES) are episodes of abnormal limb movements that resemble epileptic seizures (ES), but are not associated with organic aetiologies, and presumably manifest due to psychological distress [1]. Similarities in presentation to ES mean that patients with PNES are often misdiagnosed with epilepsy, resulting in multiple financial, social, emotional and health implications [2 –6].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
We report herein a patient with multiple atypical thymic carcinoids and asymptomatic paraneoplastic GCA. All the thymic carcinoids were diagnosed histopathologically as atypical thymic carcinoids with an intrathymic metastasis. Treatment consisted of a complete tumor resection followed by observation of the GCA without any adjuvant therapy. Subsequent positron emission tomography revealed a decrease in F-fludeoxyglucose accumulation in the systemic arteries. Based on these findings, paraneoplastic GCA was diagnosed. Thymic carcinoids rarely involve intrathymic metastasis or cause neopleonastic GCA. However, when they do, a...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 15 October 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Carmen De Caro, Luigi Francesco Iannone, Rita Citraro, Pasquale Striano, Giovambattista De Sarro, Andrew Constanti, John F. Cryan, Emilio RussoAbstractThe gut-microbiota, the complex intestinal microbial ecosystem essential to health, is an emerging concept in medicine. Several studies demonstrate a microbiota-gut-brain bidirectional connection via neural, endocrine, metabolic and immune pathways. Accordingly, the gut microbiota has a crucial role in modulating intestinal permeability, to alter local/peripheral immun...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
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