Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond.
Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond.
Trends Mol Med. 2019 Jul 19;:
Authors: Christophersen A, Risnes LF, Dahal-Koirala S, Sollid LM
Abstract
Few therapeutic and diagnostic tools specifically aim at T cells in autoimmune disorders, but are T cells a narrow target in these diseases? Lessons may be learned from celiac disease (CeD), one of the few autoimmune disorders where the T cell driving antigens are known, i.e. dietary gluten proteins. T cell clonotypes specific to gluten are expanded, persist for decades and express a distinct phenotype in CeD patients. Cells with this phenotype are increased also in other autoimmune conditions. Accordingly, disease-specific CD4+ T cells form an immunological scar in CeD and probably other autoimmune disorders. We discuss approaches how such T cells may be targeted for better treatment and diagnosis via their antigen specificity or via their expression of characteristic phenotypic markers.
PMID: 31331739 [PubMed - as supplied by publisher]
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Christophersen A, Risnes LF, Dahal-Koirala S, Sollid LM Tags: Trends Mol Med Source Type: research
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