Ciclopirox and efinaconazole transungual permeation, antifungal activity, and proficiency to induce resistance in Trichophyton rubrum.

Conclusions: Ciclopirox did not show any potential to induce resistance in T. rubrum and appears endowed of a more complete activity than efinaconazole in the management of onychomycosis, as the nail keratin is a substrate for the growth of fungal cells and the availability in large concentration just in the nail bed may not be sufficient to guarantee the complete eradication of pathogens. PMID: 31332076 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31332076?dopt=Abstract

Source: Antimicrobial Agents and Chemotherapy - July 21, 2019 Category: Microbiology Authors: Monti D, Mazzantini D, Tampucci S, Vecchione A, Celandroni F, Burgalassi S, Ghelardi E Tags: Antimicrob Agents Chemother Source Type: research