A critical evaluation of thyroid hormone measurements in OECD test guideline studies: Is there any added value?

In conclusion, the current testing approach is not providing specific information needed to assess endocrine disruption, as too often a statistical significant finding is noted and as down-stream adverse effects are not evaluated. Therefore, major modifications are urgently needed. Instead of extending the in vivo experiments, it should be investigated if in vitro assessments will provide more relevant information on human endocrine disruptor potential.
Source: Reproductive Toxicology - Category: Toxicology Source Type: research