Genes underscore five psychiatric disorders

(University of Queensland) A group of international doctors has uncovered the genes that contribute to the development of ADHD, autism spectrum disorder, bipolar disorder, major depression and schizophrenia.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 22 August 2019Source: The Lancet PsychiatryAuthor(s): Meng-Chuan Lai, Caroline Kassee, Richard Besney, Sarah Bonato, Laura Hull, William Mandy, Peter Szatmari, Stephanie H AmeisSummaryBackgroundCo-occurring mental health or psychiatric conditions are common in autism, impairing quality of life. Reported prevalences of co-occurring mental health or psychiatric conditions in people with autism range widely. Improved prevalence estimates and identification of moderators are needed to enhance recognition and care, and to guide future research.MethodsIn this systematic review and meta-analysis...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
CONCLUSIONS: We obtained novel evidence for shared biological mechanisms that act across psychiatric disorders and we showed that several gene sets that have been related to individual disorders play a role in a broader range of psychiatric disorders. PMID: 31328717 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
CONCLUSIONS: Our results suggest a causal role of insomnia in autism spectrum disorder and bipolar disorder. Future disease models should include insomnia as a factor for these two disorders to develop effective interventions. More detailed mechanism studies may also be inspired by this causal inference. PMID: 31234011 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
In conclusion, this review highlights the importance for clinicians to investigate for the presence of chronic nightmares along with other sleep difficulties (most commonly, insomnia and sleep apnea), to consider the potential influence of nightmares on the course of the primary mental disorder, and to be prepared to grant access to treatments targeting nightmares. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Source: Dreaming - Category: Psychiatry & Psychology Source Type: research
ConclusionsOur results suggest a causal role of insomnia in autism spectrum disorder and bipolar disorder. Future disease models should include insomnia as a factor for these two disorders to develop effective interventions. More detailed mechanism studies may also be inspired by this causal inference.
Source: European Psychiatry - Category: Psychiatry Source Type: research
Globally, psychiatric disorders, such as anxiety disorder, bipolar disorder, schizophrenia, depression, autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are becoming more prevalent. Although the exact pathological alterations are not yet clear, recent studies have demonstrated that widespread changes of very complex metabolic pathways may partially underlie the pathophysiology of many psychiatric diseases. Thus, more attention should be directed to metabolic-based therapeutic interventions in the treatment of psychiatric disorders. Emerging evidence from numerous studies suggests that administra...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
DISCUSSION: These results show that ADHD coaggregated with other major psychiatric disorders, specifically schizophrenia, bipolar disorder, major depressive disorder, and ASD, within families. The results suggest that public health officials and psychiatrists should closely monitor and follow the mental health of FDRs of ADHD-diagnosed individuals, such as parents and siblings of children with ADHD. PMID: 31090279 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Computerized device uses (CDU; e.g., playing computer games (CompGaming), mobile phone use (minutes/week for the last three months (PhoneUse) and total usage years), hands-free/speakerphone device use). Epidemiological associations between CDUs and psychiatric disorders are frequently reported; the biological mechanisms underlying these observations remain unknown. We investigated genetic overlap and causality between CDUs and psychiatric disorders (attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), autism spectrum disorder, major depressive disorder, alcohol dependence, bipolar disorder, anorexia nervos...
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Conclusion: Fun seeking on the BAS and frustration intolerance should be considered as targets in prevention and intervention programs for IA among adolescents with ADHD.IntroductionThe negative effects of internet addiction (IA) have become a concern in the past decades. IA is characterized by persistent internet use despite negative consequences, loss of control, preoccupation with internet use, increasing amounts of time spent online, and withdrawal symptoms (1). Internet gaming disorders are listed in the “Conditions for Further Study” section in the Fifth Edition of Diagnostic and Statistical Manual of Men...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Does Prenatal Stress Shape Postnatal Resilience? – An Epigenome-Wide Study on Violence and Mental Health in Humans Fernanda Serpeloni1,2, Karl M. Radtke1,3, Tobias Hecker4, Johanna Sill1, Vanja Vukojevic5, Simone G. de Assis2, Maggie Schauer1, Thomas Elbert1 and Daniel Nätt6* 1Clinical Psychology and Neuropsychology, Department of Psychology, University of Konstanz, Konstanz, Germany 2Department of Studies in Violence and Health Jorge Careli, National School of Public Health of Rio de Janeiro – National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz Foundation, ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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