Copper ions are novel therapeutic agents for uterine leiomyosarcoma

Multidrug resistance is a major concern in uterine leiomyosarcoma treatment. Development of effective chemotherapies and management of drug resistance in patients is necessary. The copper efflux transporter ATP7B is a member of the P-type ATPase family and is also known as a strong platinum efflux transporter. Various reports have shown the association between ATP7B and platinum resistance; however, suitable inhibitors or methods for inhibiting platinum efflux via ATP7B are not developed.

Source: American Journal of Obstetrics and Gynecology - July 23, 2019 Category: OBGYN Authors: Mamoru Kakuda, Shinya Matsuzaki, Yutaka Ueda, Mayu Shiomi, Satoko Matsuzaki, Toshihiro Kimura, Masami Fujita, Tomomi Egawa-Takata, Eiji Kobayashi, Satoshi Serada, Kiyoshi Yoshino, Tetsuji Naka, Tadashi Kimura Tags: Original Research: Gynecology Source Type: research