The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats

Conclusion: The balloon-injury induced neointimal formation of the carotid arteries is enhanced by insulin resistance. Treatment with metformin significantly attenuates neointimal hyperplasia through inhibition of smooth muscle cell proliferation, migration, and inflammation as well as by improvement of the insulin signaling pathway.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research