Inhibition of Notch1 signaling promotes neuronal differentiation and improves functional recovery in Spinal Cord injury through suppressing the activation of RhoA

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Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Original Article Source Type: research

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CONCLUSIONS: IL-19 inhibited TGF-β expression via Erk and p38 pathway. Moreover, it decreased CTGF expression to suppress α-SMA, COL-1 and fibronectin in scar tissues, thereby preventing spinal cord from compression of scar tissues. PMID: 31539104 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This study investigates whether mechanomyography (MMG) produced from contracting muscles as a measure of their performance could be a proxy of muscle fatigue during a sustained functional electrical stimulation (FES)-supported standing-to-failure task. Bilateral FES-evoked contractions of quadriceps and glutei muscles, of four adults with motor-complete spinal cord injury (SCI), were used to maintain upright stance using two different FES frequencies: high frequency (HF - 35 Hz) and low frequency (LF - 20 Hz). The time at 30° knee angle reduction was taken as the point of critical "fatigue failure", while the...
Source: Biomedizinische Technik/Biomedical Engineering - Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research
Publication date: Available online 19 September 2019Source: Brain, Behavior, and ImmunityAuthor(s): Yinghua Peng, Xiaozheng Zhang, Tianshu Zhang, Peter M. Grace, Hongyuan Li, Yibo Wang, Hang Li, Hongqian Chen, Linda R. Watkins, Mark R. Hutchinson, Hang Yin, Xiaohui WangAbstractThere is growing interest in drug repositioning to find new therapeutic indications for drugs already approved for use in people. Lovastatin is an FDA approved drug that has been used clinically for over a decade as a lipid-lowering medication. While lovastatin is classically considered to act as a hydroxymethylglutaryl (HMG)-CoA reductase inhibitor,...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Conditions:   Spinal Cord Injuries;   Pain, Neuropathic Intervention:   Device: Alpha-Stim M Sponsors:   SCI Research Advancement;   DuBois Vision Clinic Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Spinal Cord Injury Interventions:   Biological: MT-3921 Low dose;   Biological: MT-3921 High dose Sponsor:   Mitsubishi Tanabe Pharma Development America, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Spinal Cord Injuries;   Pain, Neuropathic Intervention:   Device: Alpha-Stim M Sponsors:   SCI Research Advancement;   DuBois Vision Clinic Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Spinal Cord Injury Interventions:   Biological: MT-3921 Low dose;   Biological: MT-3921 High dose Sponsor:   Mitsubishi Tanabe Pharma Development America, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Spinal Cord Injuries;   Pain, Neuropathic Intervention:   Device: Alpha-Stim M Sponsors:   SCI Research Advancement;   DuBois Vision Clinic Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Spinal Cord Injury Interventions:   Biological: MT-3921 Low dose;   Biological: MT-3921 High dose Sponsor:   Mitsubishi Tanabe Pharma Development America, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Sun JJ, Tang L, Zhao XP, Xu JM, Xiao Y, Li H Abstract Background and Objective: Diabetic neuropathic pain (DNP) is a common complication associated with diabetes. Currently, its underlying pathomechanism remains unknown. Studies have revealed that the recruitment of blood monocyte-derived macrophages (MDMs) to the spinal cord plays a pivotal role in different models of central nervous system injury. Therefore, the present study aimed at exploring the infiltration and function of MDMs in DNP using a mice model. Methods: Diabetes was induced using streptozotocin in male A/J mice. Mechanical withdrawal th...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
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