Targeting on Gut Microbial Metabolite Trimethylamine ‐N‐Oxide and Short‐Chain Fatty Acid to Prevent Maternal High‐Fructose‐Diet‐Induced Developmental Programming of Hypertension in Adult Male Offspring

ConclusionEarly intervention targeting on gut ‐microbiota‐derived metabolites TMAO and SCFAs to reprogram hypertension may have significant impact to reduce the burden of hypertension.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research

Related Links:

Publication date: Available online 19 November 2019Source: Food ChemistryAuthor(s): Shaimaa Selim, Eman HusseinAbstractThe effect of including sugar beet pulp (SBP) in laying hen diets on performance, egg quality, blood chemistry and egg lipid peroxidation was studied. A total of 200 laying hens were randomly assigned into 4 groups and were offered diets containing SBP at the level of 0%, 3%, 5% and 7%. The dietary inclusion of SBP linearly (P
Source: Food Chemistry - Category: Food Science Source Type: research
PMID: 31736395 [PubMed - in process]
Source: Canadian Journal of Dietetic Practice and Research - Category: Nutrition Authors: Tags: Can J Diet Pract Res Source Type: research
Canadian Journal of Zoology, e-First Articles. Recent studies have noted the differential effects of marine versus terrestrial diets on the carbon and nitrogen stable isotope (13C and 15N, respectively) diet-to-tissue discrimination values and incorporation rates for omnivorous and carnivorous mammals. Inaccurate estimates of these parameters may result in misrepresentation of diet composition or in the timing of diet shifts. Here, we present the results of a diet-switch experiment designed to estimate diet-to-tissue discrimination values and incorporation rates for tissues of gray wolves (Canis lupus Linnaeus, 1758) fed a...
Source: Canadian Journal of Zoology - Category: Zoology Authors: Source Type: research
es MA Abstract The sympathetic nervous system (SNS) regulates body functions in normal and pathological conditions and is characterized by the presence of a neuroplastic phenomenon, termed ganglionic long-term potentiation (gLTP). In hypertension, either in spontaneously hypertensive rats (SHR) or in humans, sympathetic hyperfunction, such as elevated SNS outflow and changes in synaptic plasticity have been described. Because enhanced SNS outflow is detected in the hypertensive stage and, more importantly, in the prehypertensive phase of SHR, here we explored whether synaptic plasticity, particularly gLTP, was mod...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
s N Abstract Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitive impairment. Long-term hypertension, complicated or not by the occurrence of ischemic stroke, is often reviewed on its vascular side, and parenchymal consequences are put aside. Here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron conne...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Applied Physiology, Nutrition, and Metabolism, e-First Articles. Gestational fructose exposure has detrimental health consequences on both the maternal and fetus or offspring in the early or later life, contributing to epidemic rise in cardiometabolic syndrome including cardiac events. l-Glutamine has been shown to mitigate cardiac metabolic stress. However, the effect of l-glutamine on cardiac hypertrophy induced by gestational fructose exposure is not known. We therefore hypothesized that l-glutamine would prevent gestational fructose-induced cardiac hypertrophy, possibly by suppression of pyruvate dehydrogenase kinase-4...
Source: Applied Physiology, Nutrition, and Metabolism - Category: Physiology Authors: Source Type: research
The objectives of this study were to determine the prevalence of IBS among endurance athletes and examine their GI symptom management strategies. A previously validated, online questionnaire assessed IBS diagnosis, the meeting of IBS diagnostic criteria (Rome III or Manning), general GI symptoms, and symptom mitigation strategies of endurance athletes. The questionnaire was distributed to United States athletes completing a marathon, ultra-marathon, half-distance triathlon, or full-distance triathlon. Medically diagnosed IBS was reported by 2.8% of endurance athletes. The total prevalence of IBS (n = 430) was 9.8% (medical...
Source: Applied Physiology, Nutrition, and Metabolism - Category: Physiology Authors: Source Type: research
Applied Physiology, Nutrition, and Metabolism, e-First Articles. The aim of this study was to investigate the effect of different doses of pre-workout sodium nitrate supplementation on nitric oxide, peroxynitrite levels, and performance parameters. Ten well-trained male subjects participated in a randomized, double-blinded, crossover study. They ingested 8, 16, and 24 mmol sodium nitrate or placebo (NaCl) dissolved in water at 2.5 h before an incremental exercise test. Respiratory gases (oxygen consumption, carbon dioxide production, respiratory exchange ratio) were measured throughout the exercise trials and 3 blood sampl...
Source: Applied Physiology, Nutrition, and Metabolism - Category: Physiology Authors: Source Type: research
ConclusionEarly intervention targeting on gut microbiota ‐derived metabolites TMAO and SCFAs to reprogram hypertension may have significant impact to reduce the burden of hypertension.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
Conclusion: Increased circulating TMAO downregulates IL-10 and promotes vascular inflammation and oxidative stress, contributing to endothelial dysfunction and hypertension in PE. PMID: 30821524 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
More News: Diets | Food Science | Hypertension | Magnesium | Nutrition | Pregnancy | Trimethylamine