New Questions on Cutting-Edge Prenatal Tests

New prenatal blood tests for genetic abnormalities such as Down syndrome are reshaping care for expectant mothers, but their rapid rollout has raised fears that poorly understood results could lead to confusion among patients and doctors.
Source: Health - Category: Pharmaceuticals Tags: FREE Source Type: news

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Publication date: Available online 19 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Daiandara Ramos Reis, Rodrigo Furtado de Carvalho, Ana Emília Farias Pontes, Fernanda de Oliveira Bello Corrêa, Cleverton Corrêa RabeloAbstractTemporomandibular disorders associated with bruxism have a high prevalence rate in the overall population, including individuals with Down syndrome (DS). Occlusal devices have been prescribed for the treatment of temporomandibular disorders and prevention of tooth wear due to bruxism. Patients with DS have restrictions concerning treatment with occlusal devices...
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Sunyoung Hwang, Jessica F. Williams, Maja Kneissig, Maria Lioudyno, Isabel Rivera, Pablo Helguera, Jorge Busciglio, Zuzana Storchova, Megan C. King, Eduardo M. TorresSummaryAn abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain largely unknown. Here, we show that aneuploidy disrupts the morphology of the nucleus. Mutations that increase the levels of long-c...
Source: Cell Reports - Category: Cytology Source Type: research
Three clinics have been rapped for misleading pregnant women by exaggerating the effectiveness of Down's Syndrome blood tests. The companies charge £650 per test.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Background: Array comparative genomic hybridization (aCGH), karyotyping and fluorescence in situ hybridization (FISH) analyses have been used in a clinical cytogenetic laboratory. A systematic analysis on diagnostic findings of cytogenomic abnormalities in current prenatal and pediatric settings provides approaches for future improvement.Methods: A retrospective analysis was performed on abnormal findings by aCGH, karyotyping, and FISH from 3,608 prenatal cases and 4,509 pediatric cases during 2008–2017. The diagnostic accuracy was evaluated by comparing the abnormality detection rate (ADR) and the relative frequency...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Facial recognition technology is upon us; phones and computers can now be unlocked with your specific facial structure using this gimmick, but it can also scarily be used to identify you from security cameras which are increasingly becoming omnipresent. As a matter of fact, Australian governments have been actively pushing for the implementation of this technology with what The Guardian calls “creative reasons” such as public transport payment and government rebates. But what about the implications of this technology in healthcare? From better diagnosis of rare conditions to ethnic discrimination, will it r...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Bioethics Future of Medicine Security & Privacy cybersecurity healthcare system facial recognition Source Type: blogs
(University of Missouri-Columbia) Down syndrome, due to an extra chromosome 21, occurs in 250,000 children and adults in the United States, making it the country's most common chromosomal disorder. Inherited heart defects, thyroid cancer, celiac disease and developmental disabilities are common Down syndrome complications. Only recently has catatonia, a behavioral condition marked by new onset immobility, mutism, withdrawal and other behavioral abnormalities, been recognized in Down syndrome.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Few health promotion interventions exist for adolescents and young adults with intellectual disabilities. This project evaluated the feasibility and satisfaction with a health promotion curriculum, Health U., adapted to a community-based setting by a nurse practitioner for individuals with Down syndrome and intellectual disabilities. Results demonstrate that this program was feasible and positively impacted participants. Caregivers of program participants were highly satisfied and would recommend this program.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Brief Report Source Type: research
Arthritis can be missed in young people with Down syndrome, who might not effectively communicate their pain, so experts recommend annual screening.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news
Conclusions and ImplicationsAlthough group differences were not found when considering parent-reported sleep problems, more frequent sleep problems were positively associated with increased forgetting by children with DS relative to those who were TD. Although future experimental work is needed to determine causality, these results suggest that improved sleep in children with DS might reduce forgetting, ultimately improving long-term recall memory.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Abstract People with Down syndrome (DS) show dysfunction of gait, expressed by disturbed character of angular changes and values of the spatiotemporal parameters as compared to the physiological norm. It is known that exercises and various activities have positive effect on balance and gait, but there are only a few scientific proofs concerning above-mentioned in people with DS. Furthermore, the effect of Nordic Walking (NW) training on gait in people with DS is unexplored. We enrolled 22 subjects with DS, aged 25-40 years, with moderate intellectual disability. Participants were randomly divided into 2 groups: NW...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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