Neonatal Alloimmune Thrombocytopenia: A Report of Four Cases.

Neonatal Alloimmune Thrombocytopenia: A Report of Four Cases. Kobe J Med Sci. 2019 Mar 05;64(6):E197-E199 Authors: Uenaka M, Morizane M, Tanimura K, Deguchi M, Ebina Y, Hashimoto M, Morioka I, Yamada H Abstract Antibodies against fetal platelet alloantigens in maternal blood cause neonatal alloimmune thrombocytopenia (NAIT). We encountered four newborns with NAIT from three women. A woman carried anti-human platelet antigen (HPA)-1a antibody, and vaginally delivered a newborn who had subarachnoid hemorrhage and platelet transfusions. She delivered the second newborn by a cesarean section who had no symptom. The second woman carried anti-human leukocyte antigen-A2 antibody and vaginally delivered a newborn who had no symptom. The third woman with a history of recurrent pregnancy losses carried anti-HPA-4b antibody, and delivered a newborn by a cesarean section who received platelet transfusions and immunoglobulin infusions. Antiplatelet antibody screening may be helpful in women who have a history of blood transfusion, or previous neonates with thrombocytopenia or intracranial hemorrhage. PMID: 31327862 [PubMed - in process]
Source: Kobe J Med Sci - Category: General Medicine Authors: Tags: Kobe J Med Sci Source Type: research