A tear fluid proteome of Parkinson's disease

Given the inaccessibility of the brain, attention has turned to body fluids, such as plasma and cerebrospinal fluid, as potential sources of diagnostic and prognostic biomarkers for neurodegenerative disease. This approach has proven successful in Alzheimer's disease (AD), but it has been much harder to find reliable fluid biomarkers for Parkinson's disease (PD) [1]. The concentration of Lewy body pathology-associated α-synuclein in cerebrospinal fluid (CSF) is reduced in PD patients, but with a large overlap between patient and control groups [2], and fluid biomarkers for neurodegeneration, such as neurofilament light (NfL), are mostly negative, at least in early stages of the disease [3].
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research