Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension.

CONCLUSIONS: Monocyte miR-27a in EVs decreases Mas receptor expression and eNOS phosphorylation in endothelium, impairs Ang-(1-7)-mediated vasodilation and causes hypertension. Understanding the contributions of EVs in the pathogenesis of hypertension may facilitate their use as a diagnostic biomarker.
PMID: 31328772 [PubMed - as supplied by publisher]

Source: American Journal of Hypertension - July 21, 2019 Category: Cardiology Authors: Zou X, Wang J, Chen C, Tan X, Huang Y, Jose PA, Yang J, Zeng C Tags: Am J Hypertens Source Type: research