Clinical manifestations and outcomes of severe warfarin overanticoagulation: from the EWA study.

CONCLUSIONS: Bleeds are not the major determinant of the poor prognosis in severe overanticoagulation, as coincidental INR ≥9 findings also associate with high mortality. KEY MESSAGES Only a quarter of AF patients with INR ≥9 suffered a bleeding event and the clinical manifestation of INR ≥9 had a significant impact on patient outcome. The 30-day mortality rate in patients with INR ≥9 was high ranging from 9.2 to 32.7%. Several significant predictors of 30-day mortality after INR ≥9 were identified. PMID: 29156997 [PubMed - indexed for MEDLINE]
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research