Comorbidity of substance misuse with anxiety-related and depressive disorders: a genetically informative population study of 3 million individuals in Sweden.

CONCLUSIONS: Substance misuse and anxiety/depression are associated at the population level, and these associations are partially explained by familial liabilities. Our findings indicate a common genetic etiology but are also compatible with a potential partially causal relationship between substance misuse and anxiety/depression. PMID: 31328718 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research

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Abstract Globally, the prevalence of metabolic syndrome (MetS) and its components which are the major cardiovascular disease (CVD) risk factors, is higher among patients with severe mental illness (SMI) compared to the general population. This is mainly due to the deleterious lifestyles characterized by physical inactivity, excessive alcohol consumption, smoking, and unhealthy diets common among patients with SMI as well as due to cardiometabolic effects of psychotropic medications. Despite these conditions being highly prevalent among patients with SMI, little attention is given to these conditions during routine...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 9 December 2019Source: Enzyme and Microbial TechnologyAuthor(s): Liuyan Gu, Haibo Yuan, Xueqin Lv, Guangsheng Li, Rigang Cong, Jianghua Li, Guocheng Du, Long LiuAbstract5-Methylpyrazine-2-carboxylic acid (MPCA) is an important pharmaceutical intermediate and is used in the production of hypoglycemic agents and lipid-lowering drugs. This work aimed to develop a whole-cell biocatalytic process for the efficient synthesis of MPCA from 2, 5-dimethylpyrazine (DMP). Firstly, a whole-cell biocatalyst Escherichia coli strain was constructed by plasmid-based expression of xylene monooxygenase (XMO...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
In conclusion, the study indicates that MFX relieves a depressive-like state in LPS-induced mice through the inhibition of the NLRP3 inflammasome and the enhancement of the neurogenesis pathway. PMID: 31814820 [PubMed - in process]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Publication date: Available online 9 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Satoshi Deyama, Ronald S. DumanAbstractClinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), contributing to neuronal atrophy in the prefrontal cortex (PFC) and hippocampus, and reduced hippocampal adult neurogenesis. Conventional monoaminergic antidepressants can block/reverse, at least partially, these ...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
CONCLUSION: Similar to the past SCID versions, kappa values were found to be quite high and all were statistically significant. The Turkish version of SCID-5/ CV can be reliably used in both clinical practice and clinical studies. PMID: 31170307 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
For something so common, anxiety is still massively misunderstood. There are myths and misconceptions about everything from what anxiety disorders look and feel like to what actually helps to treat these illnesses and navigate anxiety. Which is why we asked several anxiety experts to clear things up. Below, you’ll find their illuminating insights. Living with an anxiety disorder can be exceptionally difficult. Many people minimize and trivialize anxiety disorders. For instance, how often have you said or heard someone say “I’m sooo OCD about my desk!” or “I’m really OCD about using hand ...
Source: Psych Central - Category: Psychiatry Authors: Tags: Anxiety Cognitive-Behavioral Disorders General Psychotherapy Self-Help Stress Treatment Anxiety Disorder Treatment Anxiety Disorders Cbt exposure and response prevention therapy GAD Ocd Source Type: news
A highly effective psychotherapy called cognitive behavioral therapy (CBT) focuses on how our thoughts, beliefs, and attitudes can affect our feelings and behavior. Traditional CBT treatment usually requires weekly 30- to 60-minute sessions over 12 to 20 weeks. A faster option now emerging is intensive CBT (I-CBT), which employs much longer sessions concentrated into a month, week, or weekend — or sometimes a single eight-hour session. CBT helps people learn tools to reframe different types of thinking, such as black-and-white thinking (I can’t do anything right) and emotional reasoning (I feel you dislike me, ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Anxiety and Depression Behavioral Health Mental Health Parenting Source Type: blogs
This article reviews this relationship and provides recommendations for management. Keywords: Insomnia, sleep disorder, psychiatric disorder, depression, psychosis, schizophrenia, anxiety disorder Insomnia affects 25 million people in the United States annually and leads to an estimated $100 billion health care burden. Insomnia has also been shown to be a causal factor in other medical and psychiatric disorders, cognitive impairments, accidents, absenteeism, and reduced quality of life.1 The cost of not treating insomnia is more than the cost of treating insomnia.2 Insomnia as a symptom is seen in up to one third of the Un...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review anxiety disorder depression insomnia psychiatric disorder psychosis schizophrenia sleep disorder Source Type: research
ConclusionsThese findings add to previous reports suggesting that poorer outcome of anxiety disorders among cannabis users may be attributed mainly to differences in baseline factors and not cannabis use.
Source: Depression and Anxiety - Category: Psychiatry Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 24 June 2016 Source:The Lancet Author(s): Michelle G Craske, Murray B Stein Anxiety disorders (separation anxiety disorder, selective mutism, specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalised anxiety disorder) are common and disabling conditions that mostly begin during childhood, adolescence, and early adulthood. They differ from developmentally normative or stress-induced transient anxiety by being marked (ie, out of proportion to the actual threat present) and persistent, and by impairing daily functioning. Most anxiety disorders affect almost ...
Source: The Lancet - Category: Journals (General) Source Type: research
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