Viruses, Vol. 11, Pages 675: Δccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica

Viruses, Vol. 11, Pages 675: Δccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica Viruses doi: 10.3390/v11070675 Authors: Konstantin Kletenkov Ekaterina Martynova Yuriy Davidyuk Emmanuel Kabwe Anton Shamsutdinov Ekaterina Garanina Venera Shakirova Ilsiyar Khaertynova Vladimir Anokhin Rachael Tarlinton Albert Rizvanov Svetlana Khaiboullina Sergey Morzunov Nephropathia Epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) and linked to hantavirus infection, is endemic in the Republic of Tatarstan. Several genetic markers of HFRS severity have been identified previously, including human leukocyte antigen (HLA) complexes and nucleotide polymorphism in the tumor necrosis factor alpha (TNFα) gene. Still, our understanding of the genetic markers of NE severity remains incomplete. The frequency of the C–C chemokine receptor type 5 (CCR5) gene wild type and gene with 32-base-pair deletion (Δ32CCR5) genotypes in 98 NE samples and 592 controls was analyzed using PCR. Along with the serum levels of 94 analytes, a lack of differences in the CCR5 genotype distribution between NE cases and the general population suggests that the CCR5 genotype does not affect susceptibility to hantavirus infection. However, in NE cases, significant variation in the serum levels of the host matrix metalloproteases between functional CCR5 homozygous and Δ32CCR5 heterozygous patients was detecte...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research

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Source: NYT Health - Category: Consumer Health News Tags: Coronavirus (2019-nCoV) Epidemics Deaths (Fatalities) Politics and Government Cruises Viruses China Cambodia Hubei Province (China) Source Type: news
A taxi driver has died from the coronavirus in Taiwan, marking the first such death on the island and the fifth fatality outside mainland China from an epidemic that has curbed travel and disrupted global supply chains.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
by Yidan Li, Bernard Cazelles, Guoqing Yang, Marko Laine, Zheng X. Y. Huang, Jun Cai, Hua Tan, Nils Chr. Stenseth, Huaiyu Tian Seoul hantavirus (SEOV) has recently raised concern by causing geographic range expansion of hemorrhagic fever with renal syndrome (HFRS). SEOV infections in humans are significantly underestimated worldwide and epidemic dynamics of SEOV-related HFRS are poorly understood because of a lack of fiel d data and empirically validated models. Here, we use mathematical models to examine both intrinsic and extrinsic drivers of disease transmission from animal (the Norway rat) to humans in a SEOV-endemic ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionsThe clinical course of acute NE was similar in adults and children with high frequency of AKI as well as thrombocytopenia, but with full recovery of all patients.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conclusions/significanceThe southeastern and central Shandong Province are current key HFRS epidemic foci dominated byA.agrarius andR.norvegicus, respectively. Our study could help local departments to strengthen prevention and control measures in key areas to reduce the hazards of HFRS.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Urbanization and rural-urban migration are two factors driving global patterns of disease and mortality. There is significant concern about their potential impact on disease burden and the effectiveness of current control approaches. Few attempts have been made to increase our understanding of the relationship between urbanization and disease dynamics, although it is generally believed that urban living has contributed to reductions in communicable disease burden in industrialized countries. To investigate this relationship, we carried out spatiotemporal analyses using a 48-year-long dataset of hemorrhagi...
Source: Rural Remote Health - Category: Rural Health Authors: Tags: Proc Natl Acad Sci U S A Source Type: research
In this report, we describe anunusual case involving a pregnant woman with HFRS who was in a state of shock. Diagnoses: Hemorrhagic fever with renal syndrome and septic shock. Interventions: Timely termination of pregnancyalong with correction of the shock is very important to curb the inflammation and reduce organ damage. Outcomes: Although HFRS in pregnancy could pose a serious threat to the lives of the mother and the child. Our patient was successfully treated. Lessons: Early and accurate diagnosis, anti-shock treatment, and timely termination of pregnancyare the key aspects of therapy for HFRS with late pregnancy.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
(Kazan Federal University) Hantavirus infection is acute zoonosis clinically manifesting in two forms: Hemorrhagic Fever with Renal Syndrome (HFRS), caused by Old World hantaviruses, and Hantavirus pulmonary syndrome (HPS), caused by New World hantaviruses. Mild form of HFRS, Nephropaia epidemica (NE), is diagnosed in Tatarstan region of Russia, while HPS is endemic in Americas. Humans become infected by inhaling virus contaminated aerosol of urine and feces.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
In this study, we investigated viral RNA from 76 tissues samples (lung n=30, heart n=6, liver n=18 and kidney n=22) of infected naturall rodent hosts in the area of Central Dinarides caught in live traps. Puumala virus was extracted from 34,7% (16/46) rodents by nested reverse transcriptase polymerase chain reaction (RT-PCR) and real-time RT-PCR. Overall, 18 (21,4%) specimens of internal organs (kidney n=8, liver n=6, heart n=2 and lung n=2) were positive for PUUV. It was shown a high rodent infestation rate in a relatively low number of rodent and their organs, although mice were not caught during the time of high density...
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing piece of the puzzle is the current distribution and the genetic variation of PUUV in France, which has been overlooked until now and remains poorly understood. During a population survey, from 2008 to 2011, bank voles were trapped in eight different forests of France located in areas known to be endemic for NE o...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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