Nbn-Mre11 interaction is required for tumor suppression and genomic integrity [Medical Sciences]
We derived a mouse model in which a mutant form of Nbn/Nbs1mid8 (hereafter Nbnmid8) exhibits severely impaired binding to the Mre11−Rad50 core of the Mre11 complex. The Nbnmid8 allele was expressed exclusively in hematopoietic lineages (in Nbn−/mid8vav mice). Unlike Nbnflox/floxvav mice with Nbn deficiency in the bone marrow, Nbn−/mid8vav mice...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Jun Hyun Kim, Alexander V. Penson, Barry S. Taylor, John H. J. Petrini Tags: Biological Sciences Source Type: research