Neuronal injury biomarkers for assessment of the individual cognitive reserve in clinically suspected Alzheimer's disease

ConclusionsThese findings suggest that subjects with higher cognitive reserve had accumulated more pathology, which subsequently caused a faster cognitive decline over time. Together with previous findings suggesting that higher reserve is associated with slower cognitive decline, we propose a biphasic reserve effect, with an initially protective phase followed by more rapid decompensation once the protection is overwhelmed.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research