Matrine induces apoptosis and autophagy of glioma cell line U251 by regulation of circRNA-104075/BCL-9.
CONCLUSION: Taken together, the present findings suggested that matrine induced apoptosis and autophagy through down-regulating circ-104075 and Bcl-9 expression via inhibition of PI3K/AKT and Wnt-β-catenin pathways in glioma cells. The present study provides a foundation for further preclinical and clinical evaluations of matrine as a glioma therapy.
PMID: 31112718 [PubMed - indexed for MEDLINE]
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Chi G, Xu D, Zhang B, Yang F Tags: Chem Biol Interact Source Type: research
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