Involved-field radiation therapy for selected cases of recurrent ovarian cancer.

CONCLUSION: Our early experience demonstrates the safety and feasibility of IFRT as an effective salvage therapy and enables a "chemotherapy holiday" in selected recurrent EOC settings. The CA-125 value before IFRT (within normal range) and/or platinum sensitivity could be used as selection criteria for IFRT. PMID: 31328453 [PubMed - in process]
Source: Journal of Gynecologic Oncology - Category: OBGYN Tags: J Gynecol Oncol Source Type: research

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ConclusionsOur findings revealed that the Warburg and reverse Warburg effects coexisted in human ovarian cancer tissues, provided the first multiomics-based molecular alteration spectrum of ovarian cancer energy metabolism pathways (aerobic glycolysis, Kreb ’s cycle, oxidative phosphorylation, and lactate shuttle), and demonstrated that the antiparasite drug ivermectin effectively regulated these changed molecules in energy metabolism pathways and had strong capability to inhibit cell proliferation and cell cycle progression and promote cell apoptosi s in ovarian cancer cells. The observed molecular changes in energy...
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research
Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial cancers are primarily imported from either endometrial or fallopian tube epithelium. The prevailing paradigm in the genesis of high-grade serous carcinoma (HGSC), the most common ovarian cancer, posits development in fallopian tubes through stepwise tumor progression. In recent years, progress has been made not only in gathering terabytes of omics data but also in detailing the histologic-molecular correlations required to look into and make sense of the tissue origin of HGSC.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research
rik Clausen Marianna Nuti Aurelia Rughetti Glycosylation, the posttranslational linking of sugar molecules to proteins, is notoriously altered during tumor transformation. More specifically in carcinomas, GalNAc-type O-glycosylation, is characterized by biosynthetically immature truncated glycans present on the cancer cell surface, which profoundly impact anti-tumor immune recognition. The tumor-associated glycan pattern may thus be regarded as a biomarker of immune modulation. In epithelial ovarian cancer (EOC) there is a particular lack of specific biomarkers and molecular targets to aid early diagnosis and devel...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Abstract Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial cancers are primarily imported from either endometrial or fallopian tube epithelium. The prevailing paradigm in the genesis of high-grade serous carcinoma (HGSC), the most common ovarian cancer, posits development in fallopian tubes through stepwise tumor progression. In recent years, progress has been made not only in gathering terabytes of omics data but also in detailing the histologic-molecular correlations required to look into and make sense of the tissue origin of HGSC. This emerging paradigm is changing many ...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
As we all know, patients with epithelial ovarian carcinoma have poor prognosis and high recurrence rate. It is critical and challenging to screen out the patients with high risk of recurrence. At present, ther...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
This study shows that the RECAP test is an attractive alternative to DNA-based HRD tests, and further development of a clinical grade RECAP test is clearly warranted.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conditions:   Ovarian Cancer;   Ovarian and Fallopian Tube Cysts and Neoplasms;   Neoplasms by Site;   Neoplasms;   Genital Neoplasms, Female;   Urogenital Neoplasms;   Neoplasms, Glandular and Epithelial;   Neoplasms by Histologic Type;   Carcinoma, Ovarian Epithelial;   Ovarian  Diseases;   Adnexal Diseases;   Genital Diseases, Female;   Carcinoma;   Anlotinib;   PARP Inhibitors;   BRCA1 Mutation;   Angiogenes...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Ovarian cancer is the most lethal gynecologic malignancy. Early detection would improve survival, but an effective diagnostic test does not exist. Novel biomarkers for early ovarian cancer diagnosis are therefore warranted. We performed intraoperative blood sampling from ovarian veins of stage I epithelial ovarian carcinomas and analyzed the serum proteome. Junction plakoglobin (JUP) was found to be elevated in venous blood from ovaries with malignancies when compared to those with benign disease. Peripheral plasma JUP levels were validated by ELISA in a multicenter international patient cohort. JUP was significantly incre...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Zarychta E, Lepinay K, Szubert S, Jozwicki J, Misiak J, Brozyna A, Kosinska-Kaczynska K, Lewandowska A, Malicka E, Makarewicz A, Rhone P, Jozwicki W Abstract OBJECTIVES: Ovarian cancer is a heterogeneous disease, with a number of different histological subtypes with various responses to treatment. Wilms' tumor 1 (WT1) immunoreactivity is used to distinguish between OC's various subtypes. However, little is known about the protein's role as a prognostic factor. Thus, the main aim of our study was to evaluate the relationship between WT1 expression and patient overall survival (OS) and lymph node metastases....
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
Conditions:   Ovarian Neoplasms;   Fallopian Tube Neoplasms;   Endocrine Gland Neoplasms;   Neoplasms by Site;   Neoplasms;   Genital Neoplasms, Female;   Urogenital Neoplasms;   Neoplasms, Glandular and Epithelial;   Neoplasms by Histologic Type;   Carcinoma, Ovarian Epithelial;   Ovarian Diseases;   Adnexal Diseases;   Genital Diseases, Female;   Endocrine System Diseases;   Gonadal Disorders;   Carcinoma;   Bevaci...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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