Reactional changes in short-term levonorgestrel-releasing intrauterine system (lng-ius) use

SUMMARY OBJECTIVE: To evaluate endocervical and vaginal environment changes in women using a levonorgestrel-releasing intrauterine system (LNG-IUS). METHODS: A quasi-experimental study included sixty women who had an LNG-IUS inserted in the Family Planning Clinic of UNICAMP between April and November of 2016. Women in reproductive age, non-pregnant, without the use of antibiotics and contraceptives seeking for LNG-IUS insertion were selected for this study. All women were evaluated with regard to vaginal and endocervical pH, vaginal and endocervical Gram-stained bacterioscopy, and Pap-smear before and two months after LNG-IUS insertion. Clinical aspects such as cervical mucus, vaginal discharge, and cervical ectopy were also observed. RESULTS: After LNG-IUS insertion, there was an increase in the following parameters: endocervical pH>4.5 (p=0.02), endocervical neutrophil amount (p4,5 (p=0,02), quantidade de neutr ófilos endocervicais (p
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research

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To the Editor: I read with great interest the recent 2-part series by Waldman et  al, “Skin diseases of the breast and nipple.”1 I wish to highlight a common inflammatory condition that was briefly noted in the section on Candida mastitis, which is Raynaud phenomenon of the nipple (RPN). I believe this is an underdiagnosed and underreported cause of nipple pain in pregnant and lactating women and a treatable cause of inability to breastfeed.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD Online Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 21 March 2019Source: Microbial PathogenesisAuthor(s): Bibi Khadija, Aqsa Abbasi, Sadia Khan, Meera Nadeem, Lal Badshah, Rani FaryalAbstractObjectiveThe aim of the current study was to investigate pathogenic Candida spp. Colonization in oral cavity of postpartum females and its association with adverse pregnancy outcomes (APOs) and dental issues.MethodsSaliva samples and clinico-demographic data were collected from 267 postpartum females along with 54 non-pregnant females (Jan 2016–March 2018). Isolation of Candida was carried out by using standard microbiological methods and differe...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Bipolar disorder affects men and women in equal numbers, and the symptoms are essentially identical. But some key differences do exist—differences that might be due to biological factors, and social ones, too. For starters, research has consistently shown that women have higher rates of bipolar II disorder, “which typically presents as a chronic depressive disorder with periods of hypomania,” according to Candida Fink, MD, a board-certified child, adolescent and adult psychiatrist with a private practice in Westchester, N.Y. There’s a misconception that bipolar II disorder is less severe than bipola...
Source: Psych Central - Category: Psychiatry Authors: Tags: Bipolar Disorders Gender General Men's Issues Women's Issues Bipolar Disorder bipolar disorder and pregnancy bipolar I Bipolar Ii Gender Differences men and bipolar disorder menopause and bipolar disorder menstruation and bipolar Source Type: news
Administration of azoles, like fluconazole, in the treatment of difficult-to-treat fungal infections in pregnant women have been correlated with observations of congenital abnormalities in infants exposed in utero. Here we present developmental and reproductive toxicity data for a novel triterpenoid glucan synthase inhibitor, SCY-078, with proven anti-fungal activity against Candida, Aspergillus and Pneumocystis spp. currently in clinical development for the treatment of Vulvovaginal Candidiasis (VVC) and other severe invasive fungal infections.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: IDSOG Abstract Source Type: research
CONCLUSIONS The microecological status of pregnant women was basically the same as that of normal women. The most frequent genital tract infection was bacterial vaginosis. While bacterial vaginosis is amalgamative with vulvovaginal candidiasis and T. vaginalis infection, there was no significant difference in vaginal microecological observations among pregnant women in different age groups except that the non-albicans Candida infection incidence in the optimum reproductive age group and the T. vaginalis infection incidence in the younger age group was higher than in the other groups. PMID: 30065240 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Background: Candida spp has lately become a common etiology in female genital infections. Vulvovaginal Candidiasis (VVC) is defined as the association of signs and symptoms of vulvovaginal inflammation in the presence of Candida species and the absence of other etiologies. It is usually observed in the context of diabetes, antibiotic therapy and pregnancy, having studies that estimate that about 75% of women will have an episode in their life.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: UMP. 506 Source Type: research
ConclusionsThis study revealed a high prevalence of non-C. albicans species. The syndromic management guidelines for VVC in Burkina Faso will be revised to include a specific protocol for pregnant women.
Source: Journal of Medical Mycology - Category: Biology Source Type: research
ConclusionCette étude montre que la candidose vulvo-vaginale est fréquente chez les femmes enceintes suivies en gynécologie au niveau du centre hospitalier Mère et Enfant de Nouakchott.AbstractAimTo determine the prevalence and the associated risk factors of vulvovaginal candidiasis in pregnant women in Mauritania.Patients and methodThe study was carried out at the laboratory of the Mère et Enfant Center in Nouakchott, from November 1, 2016 to February 5, 2017. It concerned all pregnant women in the third trimester that came to the natal consultation at the gynecology service. These women...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
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