Cohort study: Chlorthalidone vs. hydrochlorothiazide for the treatment of hypertension

Source: Ann Intern Med Area: News The Annals of Internal Medicine has featured a study comparing the effectiveness and safety of chlorthalidone and hydrochlorothiazide for the treatment of hypertension in older adults.   The Canadian propensity score-matched observational cohort study with up to 5 years of follow-up, incorporated data from 29,873 identified individuals aged 66 years or older who were newly treated with chlorthalidone or hydrochlorothiazide and who were not hospitalised for heart failure, stroke, or myocardial infarction in the prior year. Each chlorthalidone recipient was matched to up to 2 hydrochlorothiazide recipients on the basis of age, sex, year of treatment initiation, and propensity score. The primary outcome was a composite of death or hospitalisation for heart failure, stroke, or myocardial infarction. Safety outcomes included hospitalisation with hypokalaemia or hyponatraemia.   The following results were reported: . During follow-up, chlorthalidone ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news