Insights into the genetic variation profile of < i > tprK < /i > in < i > Treponema pallidum < /i > during the development of natural human syphilis infection

ConclusionsThe identification of different profiles of thetprK gene in primary and secondary syphilis patients indicated that thetprK gene ofT.pallidum undergoes constant variation to result in the best adaptation to the host. The highly stable peptides found in V1 are likely promising potential vaccine components. The highly heterogenetic regions (e.g., V6) could help to understand the role oftprK in immune evasion.

Source: PLoS Neglected Tropical Diseases - July 21, 2019 Category: Tropical Medicine Authors: Dan Liu Source Type: research