Blood Protein Could Detect Cardiovascular Events

(Ivanhoe Newswire) --A pregnancy-associated plasma protein A (PAPP-A) is usually used to screen for Down syndrome in pregnant women, but now new research suggests that it could also be used as a marker of unstable plaque in coronary arteries.
Source: Medical Headlines From Ivanhoe.com - Category: Consumer Health News Source Type: news

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ConclusionsHealth-care professionals must be careful to speak in unprejudiced ways throughout the diagnostic process and present both termination and continuation of pregnancy as equally legitimate options. Nevertheless, the couples may still experience doubt and feel vulnerable following their decision to continue the pregnancy.
Source: Sexual and Reproductive Healthcare - Category: Reproduction Medicine Source Type: research
Abstract Down syndrome (DS) is an important genetic disease that besides cerebral functions involves many other body systems. The postnatal approach to treat this genetic disease includes intervention on various related diseases (e.g. heart failure, respiratory, oral, ear and hearing disorders). Different treatments proposed barely improve the quality of life of these subjects. Another approach to the treatment of DS considering the possibility to intervene on the embryo was recently proposed. This paper has reviewed different aspects of DS and has analyzed the results of DS treatment in an animal model, namely th...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
ConclusionsHealth-care professionals must be careful to speak in unprejudiced ways throughout the diagnostic process and present both termination and continuation of pregnancy as equally legitimate options. Nevertheless, the couples may still experience doubt and feel vulnerable following their decision to continue the pregnancy.
Source: Sexual and Reproductive Healthcare - Category: Reproduction Medicine Source Type: research
“I had no idea what a midwife was.” Lauren Dantzler isn’t alone. A mother of three, Dantzler had sought out Atrium Health’s Piedmont GYN/OB-Rock Hill during her first pregnancy upon the advice of a friend. She’s since relied on the certified nurse-midwives (CNM) of Atrium Health to deliv er her children, which included a high-risk pregnancy with her youngest son, Copelan. Across four OB/GYN practices, Atrium Health offers midwifery care from 18 experienced midwives. “I sing their praises…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
(CNN) — Natalie Dedreux has spent months campaigning against a plan to make a blood test for Down syndrome free in Germany. While its proponents say the prenatal test is a safer alternative to current procedures and should be available to everyone, Dedreux believes it will lead to people like her being “sorted out.” Dedreux, a 20-year aspiring journalist from Cologne, has the condition. “I am worried that if pregnant women find out their baby has Down syndrome, they will decide against us …. because they are scared,” she wrote on her blog. She has attended protests against the plan and ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Down Syndrome Source Type: news
ConclusionOur observation and the review of the literature reported the possibility of very weak mosaicism and disease ‐causing confined tissue‐specific mosaicism in fetus or alive patients with chromosome 21 aneuploidy, mainly Down syndrome. In case of clinical diagnosis suggestive of Down syndrome, attention must be paid to the risk of false‐negative test due to chromosomal mosaicism (very weak percentage, d ifferent tissue distribution). To overcome this risk, it is necessary to privilege the diagnostic techniques without culture step and to increase the number of cells and tissues analyzed, if possible. This stud...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Translocations are the most common type of structural chromosomal abnormalities. Unbalanced translocations are usually found in children who present with congenital abnormalities, developmental delay, or intellectual disability. Balanced translocations are usually found in adults who frequently present with reproductive failure; either subfertility, or recurrent pregnancy loss. Herein, we report the spectrum and frequency of translocations in a Sri Lankan cohort. A database of patients undergoing cytogenetic testing was maintained prospectively from January 2007 to December 2016 and analyzed, retrospectiv...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
ConclusionsThis study indicates that besides trisomy 21, the Oocyte Mosaicism Selection model could be extended to trisomy 13 as well. The crucial factor for trisomy 13 seems to be the pre ‐meiotic/mitotic trisomy 13 mosaicism, leading to a so‐called secondary meiotic nondisjunction of those oocytes having three copies of chromosome 13.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
This study aimed at determining if first trimester serum biomarkers could predict adverse pregnancy outcomes associated with villitis (VUE) and chronic intervillositis of unknown etiology (CIUE).Study designBetween January 2013 and June 2018, we selected from pathology department files placentas with VUE or CIUE associated with VUE and control placentas with available first trimester Down syndrome screening results. First trimester PAPP-A and βhCG levels were recorded. Placental growth factor (PlGF) levels were measured in patients with an available first trimester serum sample. Histological findings in placentas, cou...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Nuchal translucency has been a part of Prenatal Screening in Ontario since 2001, and sonographers have played a huge role in providing the majority of pregnant women with excellent quality risk prediction for Down syndrome. However, many Ontario sonographers have not been a part of the internationally recognized QA programs after their initial certification, for example, with the Fetal Medicine Foundation UK. Both internationally and nationally, authorities have recommended that anyone providing NT measurements be a part of a formal NTQA program, as it has been noted that without it, measurement quality and therefore quali...
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Source Type: research
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