Wearable artificial lung to be developed at Pitt through $3.4 million grant

(University of Pittsburgh) With the support of a $3.4 million National Institutes of Health grant, researchers at the University of Pittsburgh will develop an artificial lung to serve as a bridge to transplant or recovery in patients with acute and chronic lung failure.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Authors: Hoek RAS, Gaitanakis S, Hellemons ME PMID: 30310690 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
ConclusionIn our setting, excluding NMSC, the incidence is 8.8 times greater than estimations for the general population, with a high rate of lung cancer, so we should implement preventive and diagnostic strategies.ResumenIntroducciónLa mayor supervivencia del paciente trasplantado viene acompañada del aumento en la tasa de tumores de novo (TN) que representan la complicación tardía más frecuente. Podemos distinguir entre tumores de piel no melanoma (TPNM), síndrome linfoproliferativo postrasplante (SLPT) y tumores de órgano sólido (TOS). Nuestro objetivo es determina...
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 13 October 2018Source: The Annals of Thoracic SurgeryAuthor(s): Daniel Valdivia, Markus Kamler, Clemens AignerAbstractSevere chest wall deformities are considered a contraindication for lung transplantation. A 38-year-old male with idiopathic pulmonary fibrosis and severe pectus excavatum with a Haller-Index of 4.3 was considered eligible and listed for lung transplantation. Bilateral sequential transplantation and simultaneous correction of the pectus excavatum was performed via anterolateral thoracotomies and Nuss-bar insertion with peripheral femoro-femoral veno-arterial ECMO support. ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractRecipients of lung transplantation (LuTx) may experience impaired muscle function and bone metabolism even after rehabilitation. We investigated the potential use of musculoskeletal markers in identifying the impairment of muscle function and bone function in these patients. Biochemical parameters, bodily functions, and lung function of 37 LuTx recipients were evaluated at the time of their discharge from the hospital stay and about 6  months later. The biomarkers were also assessed in 30 healthy age and gender distribution-matched controls. Compared to controls, the negative muscle regulator myostatin was ele...
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
We describe the use of a decontamination protocol that allowed for successful lung transplantation in a cystic fibrosis patient with necrotizing pneumonia from highly antibiotic-resistant pathogens (Burkholderia and psuedomonas species). This strategy may allow for successful lung transplantation in cystic fibrosis patients with multi-drug resistant infections previously considered non-transplantable.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Kümmel A, Witt C, Schramm R, Wenker M, Buhl R, Gottlieb J Abstract In 2017 an amendment to the German transplant law concerning organ allocation and waiting list management became effective. This implies important consequences on lung transplant centers. Crucial innovations concern the transplant conference, indications for lung transplantation and waiting list management. Certain medical conditions now imply a restriction of waiting list enrollment for patients and there are new options for size-matching of donor lung and recipient. Moreover, the new amendment describes in detail how the clinical par...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Authors: Naranjo M, Lo KB, Mezue K, Rangaswami J Abstract Pulmonary hypertension is not uncommon in patients with renal disease and vice versa; therefore, influences treatments and outcomes. There is a large body of literature on pulmonary hypertension in patients with kidney disease, its prognostic implications, economic burden, and management strategies. However, the converse, namely the hemodynamic effects of pulmonary hypertension on kidney function (acute and chronic kidney injury) is less studied and described. There is also increasing interest in the effects of pulmonary hypertension on kidney transplant out...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Abstract Cystic fibrosis (CF) is the most common life-limiting genetic disease in Caucasian patients. Continued advances have led to improved survival, and adults with CF now outnumber children. As our understanding of the disease improves, new therapies have emerged that improve the basic defect, enabling patient-specific treatment and improved outcomes. However, recurrent exacerbations continue to lead to morbidity and mortality, and new pathogens have been identified that may lead to worse outcomes. In addition, new complications, such as CF-related diabetes and increased risk of gastrointestinal cancers, are c...
Source: Annual Review of Medicine - Category: General Medicine Authors: Tags: Annu Rev Med Source Type: research
Conditions:   Lung Transplant Recipient;   Donor Specific Antibodies;   Antibody Mediated Rejection Intervention:   Procedure: bronchoscopy. Sponsor:   University Hospital, Strasbourg, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 9 October 2018Source: The Annals of Thoracic SurgeryAuthor(s): William M. Whited, Jaimin R. Trivedi, Victor H. van Berkel, Matthew P. FoxAbstractBackgroundThere is not an objective method to estimate post lung transplant (LTx) survival based solely on cumulative donor risk factors.MethodsThe UNOS thoracic transplant database was queried to identify patients who underwent lung transplant between 2005 and 2015. A cox-proportional hazard model was generated using a training set to identify donor risk factors significantly associated with post-transplant survival. Significant donor risk facto...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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