Copper Detoxification Used As Crafty Defense Mechanism By The Fungus Cryptococcus neoformans

A potentially lethal fungal infection appears to gain virulence by being able to anticipate and disarm a hostile immune attack in the lungs, according to findings by researchers at Duke Medicine. Defense mechanisms used by the fungus Cryptococcus neoformans enable it to lead to fatal meningitis, which is one of the opportunistic infections often associated with death in HIV/AIDS patients, organ transplant recipients, diabetics and other immunosuppressed patients. In describing the complex process of how C...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

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Authors: Chen F, Li DY, Zhang B, Sun JY, Sun F, Ji X, Qiu JC, Parker RB, Laizure SC, Xu J Abstract There will be 642 million people worldwide by 2040 suffering from diabetes mellitus. Long-term multidrug therapy aims to achieve normal glycemia and minimize complications, and avoid severe hypoglycemic events. The appreciation of the drug-metabolizing enzymes and drug transporters as critical players in the treatment of diabetes has attracted much attention regarding their potential alterations in the pathogenesis of the disease. This review discusses pharmacokinetics-based alterations of cytochrome P450 enzymes, pha...
Source: Drug Metabolism Reviews - Category: Drugs & Pharmacology Tags: Drug Metab Rev Source Type: research
Type 2 diabetes prevents the body from responding to insulin correctly, leading to high levels of blood sugar. Some people require insulin injections, but others can manage the condition with oral or other injectable medications. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Diabetes Type 2 Source Type: news
Authors: Czemerska M, Robak T, Wierzbowska A Abstract INTRODUCTION: Acute myeloid leukemia (AML) remains a poor prognosis hematological malignancy. The introduction of aggressive chemotherapy with allogeneic stem cell transplantation has resulted in improved clinical outcomes in younger patients. However, the treatment results in unfit elderly AML population remain disappointing. New strategies should be introduced to improve the prognosis in this group of patients. Areas covered: This review presents and discusses the mechanism of action, safety and efficacy of sapacitabine in AML patients. Expert opinion: Sapacit...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Authors: Daniels LM, Kufel WD Abstract INTRODUCTION: Clostridium difficile infection (CDI) has become a significant healthcare-associated infection and is strongly associated with antibiotic use. Practice guidelines have recently been revised incorporating updated recommendations for diagnosis, treatment, and prevention. Areas Covered: This review discusses updated aspects of CDI management. New and emerging pharmacologic options for treatment and prevention are reviewed. Expert opinion: Metronidazole is associated with lower rates of treatment success compared to vancomycin and should no longer be used as primary ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
ConclusionsTransfusions are prevalent in the perioperative period after pediatric kidney transplantation. Lower pre-transplant hemoglobin increases the risk of transfusion. Graft function predicts hemoglobin levels at 3  months.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsAlthough we do not have a control group, we may speculate that patients who received treatment returned to a “standard” condition possibly improving final outcome. Protocol biopsies are a powerful diagnostic tool for the management of pediatric renal transplant recipients. In view of the lack of evidence that biopsies taken 5 years after transplantation lead to any therapeutic change, their use should be reconsidered.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
This study aimed to evaluate plasma concentrations of leptin and total ghrelin in children with chronic kidney disease (CKD) and assess their roles in protein-energy wasting (PEW).MethodsThis study consisted of three different CKD populations [CKD group (20 patients with non-dialysis CKD), dialysis group (39 patients on dialysis), and kidney transplant (KTx) group (35 KTx recipients)] and control group (18 healthy children). Plasma leptin and total ghrelin levels were measured. Multi-frequency bioimpedance analysis was used for the assessment of fat and lean mass. PEW was defined using criteria including body mass, muscle ...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Publication date: October 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 4Author(s): Tannaz Moin, Julie A. Schmittdiel, James H. Flory, Jessica Yeh, Andrew J. Karter, Lydia E. Kruge, Dean Schillinger, Carol M. Mangione, William H. Herman, Elizabeth A. Walker
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Chertok Shacham E, Ishay A PMID: 30221876 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Authors: Peled Y, Freimark D, Har-Zahav Y, Nachum E, Kogan A, Kassif Y, Lavee J Abstract BACKGROUND: Heart transplantation (HT) is the treatment of choice for patients with end-stage heart failure. The HT unit at the Sheba Medical Center is the largest of its kind in Israel. OBJECTIVES: To evaluate the experience of HT at a single center, assess trends over 3 decades, and correlate with worldwide data. METHODS: Between 1990 and 2017, we reviewed all 285  adult HT patients. Patients were grouped by year of HT: 1990-1999 (decade 1), 2000-2009 (decade 2), and 2010-2017 (decade 3). RESULTS: The percent...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
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