Post-transplant lymphoproliferative disorder presenting as T-prolymphocytic leukemia: a case report

ConclusionThe place of immunophenotyping in the diagnosis and treatment of this disorder is of significant importance. More research needs to be carried out to further comprehend the pathophysiology and treatment modalities for this disorder.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research

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OBJECTIVES: The outcomes of refractory and relapsed acute myeloid leukemia (AML) patients in developing countries are underreported, even though the similar classic regimens are widely used. METHODS: We conducted a retrospective comparison of “ MEC ” (mitoxantrone, etoposide, and cytarabine) and “ FLAG-IDA ” (fludarabine, cytarabine, idarubicin, and filgrastim) in adults with first relapse or refractory AML. RESULTS: In total, 60 patients were included, of which 28 patients received MEC and 32 received FLAG-IDA. A complete response (CR) rate of 48.3% was observed. Of the included patients, 16 (27%) ...
Source: Clinics - Category: General Medicine Source Type: research
China's Wuhan city, where the global coronavirus pandemic began, is still testing residents regularly despite relaxing its tough two-month lockdown, with the country wary of a rebound in cases even as it sets its sights on normalising the economy.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
A small Chinese city on the border with Russia is mounting an increasingly urgent defence against a surge of new coronavirus cases even as crowds return to restaurants and shops in much of the rest of the country.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
CONCLUSIONS: Overall survival was good in both subgroups and comparable to literature. The mean costs per patient differ between the watch-and-wait subgroup (€6713) and the total mesorectal excision subgroup (€17,108). No comparison between the groups could be made. Based on the results of this study, the current strategy, where patients with a clinical complete response are treated in a watch-and-wait policy, and patients with an incomplete response are treated with total mesorectal excision, is likely to be (cost)saving. See Video Abstract at http://links.lww.com/DCR/B177. RESULTADOS ONCOLÓGICOS Y COS...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
Most US coronavirus cases, especially those in New York are people infected with a strain that came from Europe, not China, but a second strain came to Washington from China, studies suggest.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
China has accused Taiwan of "venomously" attacking the World Health Organization (WHO), seeking independence and conniving with internet users to spread racist comments, after the WHO chief said racist slurs against him had come from the island.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
This study assessed the in vitro and in vivo functionality of CAR T cells transduced to express the anti-CD19 CAR of liso-cel in combination with ibrutinib or acalabrutinib. In prolonged stimulation assays, the presence of ibrutinib or acalabrutinib improved the CAR T-cell effector function. RNA-Seq analysis and surface marker profiling of these CAR T cells treated with ibrutinib but not acalabrutinib revealed gene expression changes consistent with skewing toward a memory-like, type 1 T-helper, Bruton tyrosine kinase phenotype. Ibrutinib or acalabrutinib improved CD19+ tumor clearance and prolonged survival of tumor-beari...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Basic Studies Source Type: research
We report a case of the pathologically evaluated antitumor effect of pembrolizumab, a programmed death-1 immune checkpoint inhibitor antibody, in G-CSF-producing bladder cancer. A 53-year-old male patient underwent 4 courses chemotherapy with a combination of gemcitabine and carboplatin before a radical cystectomy with ileal neobladder. Four months after the surgery, local recurrence was detected in the pelvis and therefore pembrolizumab was used. One week after its administration, the patient showed increased mucus in his urine. A computed tomography scan and cystoscopy revealed a fistula between the ileum and the neoblad...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Clinical Studies Source Type: research
We present a case of in-transit metastatic melanoma in a renal transplant patient. The patient was initially managed with talimogene laherparepvec (T-VEC) injections alone with continued local progression. Addition of topical imiquimod 5% cream to intralesional T-VEC resulted in a rapid and dramatic response, with complete clearance of the cutaneous in-transit metastases and without any sign of organ rejection. In solid organ transplant patients who lack surgical options and are not eligible for treatment with a BRAF inhibitor, and for whom treatment with checkpoint inhibitors present risk of organ rejection, T-VEC either ...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Clinical Studies Source Type: research
In this work, the authors reported the hybrid architecture of carbon nanotube (CNT)–zinc oxide (ZnO) nanowire as a multi-functional probe in amperometric immunosensor for the detection of urine albumin. Low-cost substrate such as glass is possible because of novel low-temperature growth process of CNT/ZnO nanowires as a multi-function electrode in this sensor. Based on Schottky like behaviour this structure exhibit excellent high current density to achieve higher performance. Measurement of urine albumin is a new way for early detection of diabetic and also low concentration of it in culture media is also considered ...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
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