Genetic Difference of Hypothyroidism-Induced Cognitive Dysfunction in C57BL/6j and 129/Sv Mice.

Genetic Difference of Hypothyroidism-Induced Cognitive Dysfunction in C57BL/6j and 129/Sv Mice. Neurochem Res. 2019 Jul 19;: Authors: Xu YX, Sun Y, Cheng J, Xia Q, Liu TT, Zhu DF, Xu Q Abstract Adult-onset hypothyroidism induces cognitive impairments in learning and memory. Thyroxin (T4) replacement therapy appears to be effective in biochemically restoring euthyroidism, as evidenced by serum T4 and triiodothyronine concentrations within the normal range, although some the patients still exhibit cognitive dysfunctions. Here, we investigated the cognitive functions of propylthiouracil-induced hypothyroid mice in C57BL/6j and 129/Sv strains using the passive avoidance task and the novel object recognition test. Cognitive dysfunctions in hypothyroid mice were found only in the C57BL/6j strain, not in the 129/Sv strain. Further, we found that cholinergic neurons in the basal forebrain increased the membrane potential and input resistance with decreased capacitance, and that they decreased the amplitude and width of action potential in hypothyroid mice in the C57BL/6j strain but not in those in the 129/Sv strain, compared with the controls for each strain. Additionally, the excitability of cholinergic neurons in the basal forebrain was reduced in the hypothyroid mice in the C57BL/6j strain. These results indicated that transgenic mice with the C57BL/6j genetic background are more suitable for revealing the mechanism underlying hypothyroidism-induced cognitive...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

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A national survey of physicians provides insight into the variation in clinical practices regarding the management of pregnant women with subclinical hypothyroidism.Journal of the Endocrine Society
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ConclusionsThe BR method does not increase the remission rates. It may be useful to combine L-T4 with a medium dose of methimazole when GD is difficult to manage with methimazole alone. It may represent a therapeutic option to postpone definitive treatments to a suitable age.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Conclusion For patients with Graves' disease, those with iatrogenic hypothyroidism and TSI > 2.5 times the basal level are at the highest risk for neonatal thyrotoxicosis. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: American Journal of Perinatology Reports - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Authors: Pramono LA, Yuwono A Abstract Congenital hypothyroidism is the most treatable cause of mental retardation. It is also the most prevalent congenital endocrine disorder in childhood. A dramatic improvement can be made by early detection, diagnosis, and adequate treatment of levothyroxine in patients with congenital hypothyroidism. Severe cognitive impairment is associated with persistent disease in patients who have delayed or no treatment at all. In a modern era with complete healthcare facilities in a big city like Jakarta, the prevalence late-diagnosed congenital hypothyroidism is supposed to be very low....
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
The post Do not become iodine toxic appeared first on Dr. William Davis.
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle hypothyroid iodine Source Type: blogs
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Source: Sao Paulo Medical Journal - Category: General Medicine Authors: Tags: Sao Paulo Med J Source Type: research
This study was conducted to evaluate the levels of trace metals Fe, Cr, Co, Cd, Cu, Ni, Hg, Zn, and Pb in healthy individuals and patients with thyroid disease (hyperthyroidism, hypothyroidism, and cancerous). The serum levels of 110 participants living in Birjand City, east of Iran, were collected and analyzed using ICP-MS (Agilent 7900). Results showed that the concentration levels of Cr, Co, Zn, Cd, and Pb were significantly higher at case-patients (p 0.05). In patients with high or low thyroid activity, strong mutual correlations between Cr, Ni, and Fe were noticeable (p
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
Publication date: Available online 6 November 2019Source: Clinical Epidemiology and Global HealthAuthor(s): Sai Sree Lekha Akkineni, Omair Mohammed, John Preshanth Kumar Pathiraj, Tom Devasia, Ramesh Chandrababu, Vijayanarayana KunhikattaABSTRACTBackgroundHeart failure is a syndrome, due to structural and/or functional abnormalities of the heart associated with high mortality and readmissions. Causes of readmissions are poorly understood and identifying the factors associated with readmissions are crucial to reduce poor clinical outcomes in these patients.ObjectivesThe main objective of this study was to identify the facto...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
People who develop hypothyroidism while using the mood stabilizer lithium may return to normal thyroid function after the drug is discontinued, according to astudy in theJournal of Psychopharmacology.Hypothyroidism —a condition in which the thyroid gland does not produce enough thyroid hormone—has long been known to be associated with the use of lithium. “In most patients lithium-associated hypothyroidism seems reversible once lithium has been discontinued,” wrote Ingrid Lieber, M.D., of Umea Universit y in Sweden and colleagues. “Therefore, in such cases, TRT [thyroid replacement therapy] dis...
Source: Psychiatr News - Category: Psychiatry Tags: hypothyroidism Ingrid Lieber Journal of Psychopharmacology lithium thyroid function thyroid replacement therapy Source Type: research
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