GSE123357 Mouse Estrogen Treatment Study Analysis of Peri-prostatic Fat

Contributors : Priya Bhardwaj ; Kathy X Zhou ; Akanksha Verma ; Olivier Elemento ; Andrew J DannenbergSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is associated with an increased incidence of high grade prostate cancer (PC) and worse prognosis for PC patients. Recently, we showed in men that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by macrophages surrounding dead or dying adipocytes forming crown-like structures, was associated with high grade PC. Possibly, interventions that suppress periprostatic WAT inflammation will improve outcomes for men with PC. Here, we tested the hypothesis that supplemental 17 β-estradiol (E2) could decrease periprostatic WAT inflammation in obese male mice.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research