UPMC Performs First "Breathing Lung" Transplant On East Coast Using OCS Lung

UPMC surgeons have performed a "breathing lung" transplant using a portable machine that provides a constant supply of blood and nutrients to the donor organs, which doctors say has the potential to keep them healthier and viable for longer than ever before. The double-lung transplant was performed March 4 at UPMC Presbyterian, using the Organ Care System, also known as the OCS lung, by TransMedics Inc. This is the first time the device has been used on the East Coast. The patient, a 53-year-old man from Moundsville, W.Va., had suffered from pulmonary fibrosis and pulmonary hypertension...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

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Amazing growth is evident in a number of different areas of pulmonary medicine, including the screening, diagnosis, and staging of lung cancer and the introduction of personalized treatments for chronic obstructive pulmonary disease, pulmonary hypertension, and asthma. Advances in interventional pulmonology have contributed significantly to changes in lung cancer management. This issue brings you up to speed with concise reviews that will enhance your knowledge and allow you to better serve your patients.
Source: Medical Clinics of North America - Category: Primary Care Authors: Tags: Preface Source Type: research
Authors: Ntontsi P, Detta A, Bakakos P, Loukides S, Hillas G Abstract INTRODUCTION: Severe, inadequately-controlled asthma remains a clinical challenge. For this reason, clinical trials and preclinical experimental studies on novel agents as an add-on therapies continue emerge. Phosphodiesterases (PDEs) are enzymes that regulate the function of immune cells by hydrolyzing cyclic guanosine monophosphate/cGMP and cyclic adenosine monophosphate/cAMP. PDEs are divided into subfamilies [PDE3, PDE4, PDE5 and PDE7] which are mainly found in the respiratory tract. Inhibitors of PDEs have already been approved for COPD and ...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Merck and Bayer have been granted FDA Breakthrough Device Designation for the collaborative Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Artificial Intelligence Pattern Recognition software. CTEPH can be difficult to diagnose because its symptoms are similar to asthma and chronic obstructive pulmonary disease symptoms. CTEPH affects five people per million annually worldwide. Computed tomography pulmonary angiography and a ventilation/perfusion scan can be used to determine if thromboembolic occlusion is causing pulmonary hypertension in patients. Get the full story on our sister site, Medical Design &Outsourc...
Source: Mass Device - Category: Medical Devices Authors: Tags: Food & Drug Administration (FDA) Bayer Merck Source Type: news
Bayer announced in a release that the U.S. Food and Drug Administration granted a breakthrough device designation for an AI pattern recognition software that it is jointly developing with Merck. The software is designed for the treatment of chronic thromboembolic Pulmonary Hypertension (CTEPH), a rare form of pulmonary hypertension that is often difficult to diagnose because symptoms often mimic those of asthma or chronic obstructive pulmonary disease (COPD). Working together, Bayer and Merck have…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
CONCLUSIONS: Although the diabetes-lung association is epidemiologically and clinically well-established, especially in asthma, the underlying mechanism and pathophysiology are not been fully understood. Several mechanisms have been suggested, mainly associated with the pro-inflammatory and proliferative properties of diabetes, but also in relation to micro- and macrovascular effects of diabetes on the pulmonary vasculature. Also, hypoglycemic drugs may influence lung diseases in different ways. For example, metformin was considered a potential therapeutic agent in lung diseases, while insulin was shown to exacerbate lung ...
Source: Review of Diabetic Studies - Category: Endocrinology Tags: Rev Diabet Stud Source Type: research
AbstractIntroductionRecurrent hypoxia makes asthmatics at risk for pulmonary hypertension and ventricular dysfunction. Early stages of these cardiovascular diseases cannot be detected by conventional echocardiography. Tissue Doppler imaging has been introduced recently as a more sensitive&more accurate tool for investigating cardiovascular diseases.Objectiveinvestigating ventricular functions in asymptomatic asthmatic children using tissue Doppler echocardiography.Method50 asthmatic children and 50 controls were examined by conventional echocrdiography. Tissue Doppler echocardiography was performed to measure the myoca...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
ConclusionIncreased serum NT ‐proBNP is associated with subclinical RV dysfunction in asthmatic children. RV function is significantly affected in children with bronchial asthma.
Source: Pediatrics International - Category: Pediatrics Authors: Tags: Original Article Source Type: research
The objective of this abstract is to evaluate preliminary clinical outcomes of the integrated SCD-pulmonary clinic during the intervention phase (July 2017-June 2018) compared to 24 months prior to implementation (July 2015-June 2017). We hypothesized an integrated clinic model would improve access to specialized pulmonary care for children with SCD and reduce hospitalizations for vaso-occlusive episodes (VOEs). The primary endpoints are adherence to pulmonary clinic appointments and unplanned acute healthcare utilization for SCD-related complications and/or asthma exacerbations. Secondary endpoints are the number of unpla...
Source: Blood - Category: Hematology Authors: Tags: 901. Health Services Research-Non-Malignant Conditions: Poster III Source Type: research
Conclusion: Despite the development of treatments, the recent implementation of screening programs, the prognosis for PAH remains reserved.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
Aim: Novel therapies exist for severe asthma. We analyzed asthma features in patients with severe COPD to identify potential therapy candidates.Method: We undertook a cross-sectional analysis of 80 consecutive patients with severe COPD, GOLD IV/D (ex-smokers of>6 months, pack years 36±21). Patients were examined for history of allergy, asthma, exacerbation rate, lung function tests, 6-minute walk test, skin prick test, fractional exhaled nitric oxide (FENO), normal and induced sputum, differential blood count and serum immunoglobulin. Right-heart catheterisation and chest CT were carried out.Results: 80 patients ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
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