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UPMC Performs First "Breathing Lung" Transplant On East Coast Using OCS Lung

UPMC surgeons have performed a "breathing lung" transplant using a portable machine that provides a constant supply of blood and nutrients to the donor organs, which doctors say has the potential to keep them healthier and viable for longer than ever before. The double-lung transplant was performed March 4 at UPMC Presbyterian, using the Organ Care System, also known as the OCS lung, by TransMedics Inc. This is the first time the device has been used on the East Coast. The patient, a 53-year-old man from Moundsville, W.Va., had suffered from pulmonary fibrosis and pulmonary hypertension...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

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In conclusion, the presence of negative T waves in both leads III and V1 allows PE to be differentiated simply but accurately from ACS in patients with negative T waves in the precordial leads. "Witting et al. looked at consecutive patients with PE, ACS, or neither. They found that only 11% of PE had 1 mm T-wave inversions in both lead III and lead V1, vs. 4.6% of controls.  This does not contradict the conclusions of Kosuge et al. that when T-wave inversions in the right precordial leads and in lead III are indeed present, then PE may indeed by more common. ...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Conclusion: Our study highlights how the ACOS phenotype may clinically differ from their counterparts elsewhere, making it a clinical challenge to identify them in India.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Heat shock proteins (HSPs), also known as stress proteins, constitute a complex network of proteins highly conversed across species that have been classified into different families according to their molecular weight: HSP110, HSP90, HSP70, HSP60, HSP40 and the small HSPs [1]. Although they are mainly known for their chaperone and cytoprotective properties, HSPs also participate in the regulation of many cellular signalling processes [2]. These proteins have been involved in various physiological as well as pathological conditions, including respiratory diseases such as asthma, chronic obstructive pulmonary disease, sarcoi...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung biology and experimental studies, Interstitial and orphan lung disease Editorials Source Type: research
Authors: Mokry J, Urbanova A, Medvedova I, Kertys M, Mikolka P, Kosutova P, Mokra D Abstract Selective phosphodiesterase (PDE) 4 inhibitors have recently been introduced into the therapy of chronic obstructive pulmonary disease. However, suppression of airway reactivity and eosinophilic inflammation by increased intracellular cAMP could be beneficial in bronchial asthma as well. PDE5 inhibitors are used for the therapy of erectile dysfunction, pulmonary hypertension, and other cardiovascular diseases, but an expression of PDE5 in several immune cells suggests its perspectives in inflammation, as well. To bring a ne...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
We present a case of severe idiopathic pulmonary arterial hypertension in a 20-year-old patient with ongoing breathlessness. She was initially diagnosed with asthma and panic attacks in community care. As the symptoms became progressively worse, she was referred for pulmonary hypertension clinic assessment. Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) showed grossly abnormal perfusion defects which were mismatched to the ventilation scan, suggestive of chronic thromboembolic disease.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Image Source Type: research
AbstractPurpose of ReviewThe purpose of this article is to provide a brief review of the preoperative pulmonary evaluation of patients undergoing non-thoracic surgery, focusing on risk factor identification, assessment of specific high-risk populations, and strategies to minimize postoperative pulmonary complications (PPCs).Recent FindingsAlong with traditional risk factors, recent risk stratification indices have been developed and validated to help quantify risk of PPCs. Careful history and physical examination are key elements in the pulmonary evaluation of all pre-surgical patients. Patients with chronic obstructive pu...
Source: Current Anesthesiology Reports - Category: Anesthesiology Source Type: research
Abstract Interleukin (IL)-5 is a critical regulator of eosinophils and a therapeutic target for asthma. The administration of anti-IL-5 or anti-IL-5 receptor (IL-5R) antibodies has been shown to reduce eosinophil counts and ameliorate asthmatic symptoms in studies on animal models of allergy as well as in human clinical trials. In order to explore other potential clinical uses of IL-5R antibodies, we used an animal model of IL-33-mediated pulmonary arterial hypertrophy. We first generated chimeric monoclonal antibodies against the mouse IL-5 receptor α chain (IL-5Rα), which comprised an Fc region from ...
Source: Immunobiology - Category: Allergy & Immunology Authors: Tags: Immunobiology Source Type: research
Conclusions: The body composition with subjects with HF and COPD showed a high deterioration that can lead to a worse condition.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Asthma Source Type: research
Recent studies have shown research CT scan PA:A ratios>1 to correlate with pulmonary hypertension (PH) and be predictive of acute exacerbations of COPD (AECOPD). This predictive ability has yet to be demonstrated using non-research CT scans at the community level. Before determining if the PA:A of real-world CT scans could be used to predict AECOPD in community practice, we felt it important to measure the reproducibility of the PA:A as determined by non-radiologists in the community setting. From a database of 1040 clinical scans, 33 scans from 6 subjects (4 COPD, 1 asthma, 1 PH) were selected to measure the PA:A. A me...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Imaging Source Type: research
Introduction: Patients with Chronic Obstructive Pulmonary Disease (COPD) are characterized by reduces muscle mass. In COPD patients, the Pulmonary Hypertension (PH) is a predictor for long hospitalization days. The body composition screening by bioelectrical impedance vector analysis (BIVA) permits to identify the resistance (R) and reactance (Xc). The have a negative correlation with muscle mass and or total corporal water while Xc reports a positive correlation with the cell membrane integrity.Objective: To evaluate the body composition in patients with COPD and PH.Methods: Cross sectional study in 102 subjects older tha...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research
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