UPMC Performs First "Breathing Lung" Transplant On East Coast Using OCS Lung

UPMC surgeons have performed a "breathing lung" transplant using a portable machine that provides a constant supply of blood and nutrients to the donor organs, which doctors say has the potential to keep them healthier and viable for longer than ever before. The double-lung transplant was performed March 4 at UPMC Presbyterian, using the Organ Care System, also known as the OCS lung, by TransMedics Inc. This is the first time the device has been used on the East Coast. The patient, a 53-year-old man from Moundsville, W.Va., had suffered from pulmonary fibrosis and pulmonary hypertension...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

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Publication date: Available online 30 October 2018Source: Life SciencesAuthor(s): Haojun Xie, Liquan Wu, Zhenan Deng, Yating Huo, Yuanxiong ChengAbstractThe YAP and TAZ, as the downstream effectors of Hippo pathway, have emerged as important translational co-activators of a wide variety of biological processes. YAP/TAZ plays a crucial role in the lung development and physiology. Dysregulation of YAP/TAZ signaling pathway contributes to the development and progression of chronic lung diseases, including lung cancer, pulmonary fibrosis, pulmonary hypertension, COPD, asthma, and lung infection. Therefore, owing to its critica...
Source: Life Sciences - Category: Biology Source Type: research
We report a case of a 29-year-old female with a history of asthma, post-partum ARDS, and pulmonary hypertension who presents with severe shortness of breath. The patient describes her shortness of breath as progressive over the past 10  years. Chest radiography and CT angiography of the thorax showed findings consistent with fibrosing mediastinitis with severe stenosis of the left main pulmonary artery. This resulted in appearance of unilateral absent left lung perfusion on quantitative Tc-99-MAA perfusion and Xe-133 ventilation (V/Q) scan.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
This case was written by one of ourgreat Hennepin 2nd year residents, Aaron Robinson, with lots of comments and edits by Smith.Thanks to Dr. Smith and Dr. Travis Olives for being part of this case. A 12 year old girl with a history of mild intermittent asthma presented to the emergency department with worsening shortness of breath over the past couple of days. She is up to date on her vaccinations and has no PMHx besides asthma and a noncontributory family history. She does not identify any specific triggers for her asthma. Initial screen in triage revealed normal vitals signs and a normal temperature. Upon interviewi...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
A 70-year-old lady presented to the dermatology clinic with a left shoulder lesion which did subsequently spread and involved both her buttock area. The lesions were asymptomatic most of time. Occasionally they became pruritic. She was otherwise well with a history of cystinuria, hypertension, asthma, pulmonary hypertension and brochiectasis for which she was on multiple medications including Thiola (tiopronin) tablets. On examination she had multiple annular lesions with a rim of erythema spread throughout her trunk.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
CONCLUSION: TPE should always be considered in patients from filaria endemic areas presenting with cough, dyspnea or wheezing. High eosinophil count (>3 × 10 9 cells) with raised IgE level (>1000 IU/ml) in such cases should alert the physician to look for TPE. Early diagnosis and treatment can prevent disease progression and complications. PMID: 29969926 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
In conclusion, systemic vasculitis is a frequent cause of respiratory system involvement wit h diverse manifestations of distinct severity and outcome.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
The objective of this task force was to issue a statement with research recommendations about lung disease models by facilitating in-depth discussions between respiratory scientists, and to provide an overview of the literature on the available models. Focus was put on their specific benefits and limitations. This will result in more efficient use of resources and greater reduction in the numbers of animals employed, thereby enhancing the ethical standards and translational capacity of experimental research. The task force statement addresses general issues of experimental research (ethics, species, sex, age, ex vivo and i...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: ERS statement Source Type: research
Conclusions: SP-B pre-proteins might serve as a biomarker in pulmonary diseases with alveolar or interstitial damage such as ILDs, especially in IPF. Their role in the long-term monitoring of such diseases has to be clarified further.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
In conclusion, the presence of negative T waves in both leads III and V1 allows PE to be differentiated simply but accurately from ACS in patients with negative T waves in the precordial leads. "Witting et al. looked at consecutive patients with PE, ACS, or neither. They found that only 11% of PE had 1 mm T-wave inversions in both lead III and lead V1, vs. 4.6% of controls.  This does not contradict the conclusions of Kosuge et al. that when T-wave inversions in the right precordial leads and in lead III are indeed present, then PE may indeed by more common. ...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Conclusion: Our study highlights how the ACOS phenotype may clinically differ from their counterparts elsewhere, making it a clinical challenge to identify them in India.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
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